摘要
目的探讨动脉粥样硬化型脑梗死患者同型半胱氨酸(Hcy)水平及其与预后的关系。方法采用前瞻性队列研究方法连续登记2010-01—2013-05入住我科脑梗死患者,并进行TOAST分型,其中Ⅰ型入选为研究组,对照组为同期健康体检者,均行Hcy水平检测,对脑梗死患者入院时及3个月后采用美国国立卫生院神经功能缺损评分量表(NIHSS)及改良Rankin量表评分(MRS)进行评价,并对数据进行分析。结果研究组Hcy水平较对照组明显升高,差异有统计学意义(P<0.05);研究组Hcy水平与入院时NIHSS、MRS评分无相关性(P>0.05),但与3个月后NIHSS和MRS改善程度相关(P<0.05),>15.57μmol/L患者预后差。结论血浆Hcy水平增高可能是脑梗死的危险因素,可反映预后转归情况。
Objective To investigate the level of homocysteine (Hcy) and the relationship between homocysteine and prog-nosis in atherosclerotic patients with cerebral infarction· Methods Cerebral infarction patients in our hospital from January 2010 to May 2013 were classified according to TOAST ,and then the TOAST-Ⅰpatients were considered as the research group and the healthy people at the same time were considered as the control group· The Hcy levels of two groups on admission and 3 months after treatment were evaluated by the NIHSS and MRS scores·Results The Hcy level of research group was higher than that of control group;the Hcy level of research group was related with or without the NIHSS and MRS scores (on admis-sion or 3 months after treatment)· The Hcy >15·57 μmol/l group had a worse prognosis· Conclusion Increased Hcy level may be the risk factors for patients with cerebral infarction ,which can reflect the patient’s prognosis.
出处
《中国实用神经疾病杂志》
2014年第21期31-33,共3页
Chinese Journal of Practical Nervous Diseases
