摘要
目的通过对巨大型胃肠间质瘤(GIST)的诊断和手术方式进行探索,为临床治疗巨大型GIST提供新思路。方法对16例巨大型GIST患者一般资料、影像学资料、手术方式、随访指标进行回顾性调查,并进行统计学分析。结果 11例服用甲磺酸伊马替尼患者无复发生存期1 a以上,而5例未服用伊马替尼治疗患者1 a内复发,中位无复发生存期为33个月。COX多因素分析显示,肿瘤部位、术中肿瘤有无破裂、是否使用伊马替尼治疗与患者预后有关(P<0.05),可作为患者预后的独立因素。结论巨大型GIST在选择手术时,应遵循术前影像学评估、术前服用甲磺酸伊马替尼治疗缩小肿瘤和手术切除时边缘切净为3大原则,这对于改善患者预后和延长生存期有益。
Objective To explore the method of surgical resection and diagnosis of giant gastrointestinal stromal tumors( GIST). Methods A retrospective survey was done among 16 patients with giant GIST of general information,imaging,surgical procedures,follow-up and outcome measures and statistical analysis. Results The free recurrence survival time was more than 1 year of 11 patients taking imatinib treatment,5 patients with no imatinib treatment were recurrent within 1 year,the median free recurrence survival time was 33 months. COX multivariate analysis showed that the location,presence or absence of intraoperative tumor rupture,whether imatinib treatment had a clear correlation with prognosis( P < 0. 05). Conclusion Different ways of surgical treatment combining with digestive tract reconstruction is the gold standard of treatment of giant GIST. The three principle are followed by the imaging evaluation,shrink treatment the tumor as possible,resection of the tumor edge as more as possible,respectively.These principle can improve the prognosis and survival of giant GIST.
出处
《肿瘤基础与临床》
2016年第2期135-138,共4页
journal of basic and clinical oncology
基金
国家自然科学基金项目(编号:812111102
81171986
81271815)
河南省科技攻关项目(编号:142102310330
152102310180
162102310153)
河南省基础与前沿技术研究计划项目(编号:122300410102)
河南省教育厅自然科学基础研究计划项目(编号:12A320053)
郑州市普通科技攻关计划项目(编号:141PPTGG454)
郑州市国际合作及交流项目(编号:141PGJHZ539)
郑州大学第一附属医院院内青年创新基金项目
关键词
巨大型胃肠间质瘤
手术治疗
生存期
giant gastrointestinal stromal tumors
surgical resection
survival time
