摘要
目的研究非生物型人工肝对肝衰竭患者临床效果及预后的影响。方法肝衰竭患者102例随机分成观察组与对照组,每组51例。观察组进行非生物型人工肝治疗方法,对照组进行常规药物治疗方法。比较2组患者8、12、48周治疗效果。以及凝血功能,肝功能,症状等生化指标情况,以及患者治疗生存情况。结果观察组患者血清ALT,总胆红素TBil,与治疗前均有所下降;凝血功能方法,原活动度PTA均有所上升为6.99%,差异有统计学意义(P<0.05)。持续8周治疗过后,观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。持续12周治疗后,观察组患者生存率明显高于对照组,差异有统计学意义(P<0.05)。持续48周治疗后,观察组患者生存天数平均为(191.8±10.3)d,对照组患者生存天数平均为(159.4±20.1)d,且2组患者1年后总有效生存率,观察组43.14%,是明显高于对照组患者41.18%,2组数据差异明显有统计学意义(P<0.05)。结论对肝衰竭患者通过使用非生物型人工肝临床效果明显,不过生存率未能提高。
Objective To investigate the effects of non-biological artificial liver on the clinical outcome and prognosis of patients with liver failure.Methods A total of 102 patients with liver failure who were admitted and treated in our hospital from January 2015 to December 2015 were randomly divided into observation group(n=51)and control group(n=51).The patients in observation group were treated by non-biological artificial liver,however the patients in control group were treated by conventional drug therapy.The therapeutic effects of two groups were observed and compared at 8 w,12 w,and 48 w after treatment.Moreover the coagulation function,liver function,symptoms and other biochemical indicators,as well as the patient’s survival status were observed and compared between the two groups.Results After treatment the serum levels of ALT and total bilirubin(TBil)in observation group were significantly decreased,as compared with those before treatment.Moreover the coagulation function,the original activity PTA were significantly increased by 6.99%,there were statistically significant differences(P<0.05).After 8-week treatment,the effective rate in observation group was significantly higher than that in control group(53.24%vs 36.53%,P<0.05).After 12-week treatment,the survival rate in observation group was significantly higher than that in control group(51.17%vs 43.14%,P<0.05).After 48-week treatment,the average survival time and the total effective survival rate after one year in observation group were significantly higher than those in control group(191.8±10.3 vs 159.4±20.1,43.14%vs 41.18%,P<0.05).Conclusion The clinical effects of non-biological artificial liver in treatment of liver failure are quite significant,but the survival rate of patients can not be improved.
作者
兰玲鲜
苏春雄
LAN Lingxian;SU Chunxiong(Nanning Fourth People’s Hospital of Guangxi Zhuang Autonomons Region,Guangxi,Nanning 530023,China)
出处
《河北医药》
CAS
2019年第4期601-603,共3页
Hebei Medical Journal
基金
南宁市科学研究与技术开发计划项目(编号:20163013)
关键词
人工肝
非生物型人工肝
肝衰竭
临床效果
预后影响
artificial liver
non-biological artificial liver
liver failure
clinical curative effects
prognosis
