摘要
目的:了解武汉市水果湖社区老年人非酒精性脂肪肝(NAFLD)的流行及危险因素。方法:收集3 468例60岁以上社区老年人群的体检资料,对比分析NAFLD组与非NAFLD组之间高血压、糖尿病、肥胖、代谢综合征、骨质疏松的患病率;比较体质量指数(BMI)、腰围、腰围身高比(WHtR)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、尿酸(UA)等,并采用多因素Logistic回归分析NAFLD的危险因素。结果:老年NAFLD患病率44. 43%,女性明显高于男性,NAFLD组的BMI、腰围、WHtR、FBG、TC、TG、LDL-C、ALT、AST、UA均高于非NAFLD组,而HDL-C低于非NAFLD组,NAFLD组高血压、糖尿病、肥胖、代谢综合征的患病率也明显高于非NAFLD组。多因素Logistic回归分析显示NAFLD的危险因素为女性、高血压、代谢综合征、腰围、肥胖、TG、LDL-C、ALT>40 U/L、UA,而HDL-C为保护因素。结论:武汉市水果湖社区老年人NAFLD患病率较高,尤其是老年女性,NAFLD与高血压、代谢综合征、高血脂、高ALT、高尿酸血症等密切相关,而与糖尿病、骨密度水平相关性不明显。
Objective:To explore the prevalence and risk factors of non-alcoholic fatty liver disease(NAFLD)in the elderly in Shuiguohu community of Wuhan,a city of central China.Methods:Total3 468 subjects over 60 years old were divided into NAFLD group and non-NAFLD group,data of clinical parameters,and medical history of the subjects were collected and analyzed.Multivariate logistic regression was used to analyze the risk factors of NAFLD.Results:The prevalence of NAFLD was 44.43%,higher in females than in males.Body mass index(BMI),waist circumference,waist to height ratio(WHtR),fasting blood-glucose(FPG),total cholesterol(TC),triglycerides(TG),lowdensity lipid cholesterol(LDL-C),alanine transaminase(ALT),aspartate transaminase(AST),uric acid(UA)were significantly increased while high-density lipid cholesterol(HDL-C)was significantly decreased in NAFLD group.Meanwhile,the incidence rates of hypertension,diabetes,and metabolic syndrome were also significantly higher in the NAFLD group.Multivariate logistic regression analysis showed that female,hypertension,metabolic syndrome,waist circumference,obesity,TG,LDLC,ALT>40 U/L,and UA were independent risk factors of NAFLD,while HDL-C was a protective factor.Conclusion:The prevalence of NAFLD was relatively higher in elderly people in Shuiguohu community of Wuhan,particularly in elderly females NAFLD was closely related to hypertension,metabolic syndrome,hyperlipidemia,high ALT levels and hyperuricemia,instead of diabetes and calcaneal bone density.
作者
帅建
匡爱霞
王忠莉
林杰
张玲
SHUAI Jian;KUANG Aixia;WANG Zhongli;LIN Jie;ZHANG Ling(Dept.of Internal Medicine&Geriatrics,Zhongnan Hospital of Wuhan University,Wuhan 430071,Hubei,China;Hospital of Shuiguohu Community of Wuchang District,Wuhan 430071,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2019年第5期796-800,共5页
Medical Journal of Wuhan University
关键词
非酒精性脂肪肝
老年人
流行
危险因素
Elderly
Non-Alcoholic Fatty Liver Disease
Prevalence
Risk Factors
