摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆硫化氢(H2S)水平的变化及其临床意义。方法选取2011年1月至2015年1月我院呼吸科门诊和住院经多导睡眠仪(PSG)监测符合OSAHS的患者86例,其中轻度组25例,中度组32例,重度组29例,同期门诊体检健康者28例为对照组。四组入选者均在PSG监测次日晨醒后测定空腹血浆H2S水平,比较各组血浆H2S水平并分析其与PSG监测指标呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSp O2)的关系。结果轻度组患者血浆H2S水平为(41.23±1.63)μmol/L,与对照组的(42.12±2.11)μmol/L比较差异无统计学意义(P>0.05),但中、重度组患者血浆H2S水平[(34.61±1.79)μmol/L]和(31.71±2.01)μmol/L]与对照组比较差异均有统计学意义(P<0.01);轻、中、重度三组患者血浆H2S水平呈逐渐下降,差异均具有统计学意义(P<0.01);血浆H2S水平与AHI呈负相关(轻度组:r=-0.285,P=0.026;中度组:r=-0.384,P=0.002 1;重度组:r=-0.422,P=0.006 5),与LSp O2呈正相关(轻度组:r=0.395,P=0.002 3;中度组:r=0.422,r=0.002 1;重度组:r=0.483,P=0.001)。结论 OSAHS患者血浆H2S水平下降,不仅和疾病严重程度相关,还和夜间缺氧程度有关,临床上血浆H2S可作为评估OSAHS患者病情严重程度的一个方便简易监测指标。
Objective To investigate the changes of plasma hydrogen sulfide(H2S) and its clinical significance in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods A total of 86 patients with OSAHS,who admitted to Department of Respiratory of our hospital from January 2011 to January 2015 and checked with polysomnography(PSG), were selected as the research objects and divided into the mild group(n=25), the moderate group(n=32)and the severe group(n=29). Meantime, 28 cases of healthy volunteers were chosen as the control group. The fasting plasma H2 S level of these 4 groups were measured and compared at the next day after PSG monitoring, and the relationship between level and apnea-hypopnea index(AHI) and lowest oxygen saturation(LSp O2) were analyzed. Results There was no significant difference between the mild group(41.23±1.63) μmol/L and the control group(42.12±2.11) μmol/L in theplasma H2 S level(P>0.05). However, the plasma H2 S level of the severe group(34.61±1.79) μmol/L and moderate group(31.71 ± 2.01) μ mol/L were significantly lower than that of the control group(P<0.01). The plasma H2 S levels of three groups(mild, moderate and severe) were gradually decreased, and the differences were statistically significant(P<0.01).There was a negative correlation between plasma H2 S levels and AHI(mild group: r=-0.285, P=0.026; moderate group:r=-0.384, P=0.0021; severe group: r=-0.422, P=0.006 5); there was a positive correlation between plasma H2 S levels and LSp O2(mild group: r=0.395, P=0.002 3; moderate group: r=0.422, P=0.002 1; severe group: r=0.483, P=0.001).Conclusion The decrease of the levels of plasma endogenous H2 S in patients with OSAHS is not only related to the severity of the disease, but also to the degree of hypoxia in the night. The decrease of endogenous H2 S may affect the incidence of OSAHS, which can be used as a monitoring index of OSAHS severity.
出处
《海南医学》
CAS
2016年第19期3149-3151,共3页
Hainan Medical Journal
基金
湖北省2010年度武汉市卫生局临床医学科研项目(编号:武卫[2010]42号)
