摘要
目的:比较气囊扩张及肉毒杆菌毒素治疗贲门失弛缓症的近、远期疗效。方法:对31例患者(扩张组18例,注射组13例)进行1个月和1年随访观察,通过对临床症状、X线钡餐检查、胃镜检查和食管测压等进行比较分析。结果:18例行肉毒杆菌毒素注射患者治疗前,下食管括约肌静息压(LESP)为(8.34±1.62)kPa,松弛率(LESR)为(30.45±3.36)％。治疗后1周LESP,降至(4.13±0.42)kPa,LESR为(50.87±3.47)％。13例行气囊扩张术患者治疗前LESP为(7.58±1.48)kPa,LESR为(29.45±2.29)％。治疗后1周LESP降至(4.53±0.38)kPa,LESR为(48.47±3.32)％。两者运动学参数改善无明显差异,但行气囊扩张术有贲门黏膜撕裂、擦伤、渗血等并发症。结论:肉毒杆菌毒素注射和气囊扩张均为治疗贲门失弛缓症安全有效的方法,但气囊扩张术并发症更多。
Objective: To evaluate the curative effect of balloon dilatation or botulinum toxin (BT) local injection on achalasia. Metheods: Thirty one patients with achalasia were divided into two groups, one group balloon dilation( n = 18) and another BT local injection ( n = 13), All cases were followed up 1 to 12 mouths. The clinical manifestation, esophagram, gastroscopy and esophagus pressure of two groups were analyzed. Results: Before local injection the lower esophagus sphincter pressure(LESP) was (8. 34 ± 1. 62) kPa and the taxation rate (LESR) (30. 45±3. 36)%. After injection the LESP was (4. 13±0. 42) kPa and LESR (50. 87± 3. 47)%. Before the treatment of ballon dialation LESP was(7. 58±1. 48) kPa and LESR (29. 45±2. 92)%. After treatment of ballon dialation the LESP was(4. 53±0. 38) kPa and LESR (48. 47±3. 23)% . There was no significant difference in esophagus kinematics between two groups. But there were mucosal laceration, abrasions and hemorrhage effusion in the group of ballon dilation. Conclusions: The two methods are all effective in treating achalasia, but it seems that the balloon dilation group may have more complications.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2003年第1期51-53,共3页
Journal of Nanjing Medical University(Natural Sciences)
