摘要
目的 :探讨原发性肾病综合征 (PNS)患者体内氧化损伤状态和抗氧化系统的改变。方法 :测定了 38例肾病综合征患者的血清丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GSH -PX)及血清和红细胞超氧化物歧化酶(SOD)的含量 ,并与正常对照组进行了比较。结果 :38例PNS患者血清丙二醛水平明显高于正常对照组 ,有显著性差异 (P <0 .0 1) ;GSH -PX、血清SOD ,红细胞SOD及SOD/MDA均明显低于正常对照组 ,有显著性差异 (P <0 .0 1)。结论 :脂质过氧化物参与了肾病综合征的致病 ,以及肾病综合征患者抗氧化能力下降导致了肾病综合征患者的发病。
Objective: To study the change of oxidation system and Antioxidation system on Nephrotie syndrome patient. Method:Serum MDA , GSH-PX, SOD and SOD in red cell of 38 Nephrotic syndrome patients and 16 normal people were detected. Results:The serum MDA level of 38 Nephrotic syndrome patients was significantly higher than that of 16 normal people( P <0.01);the serum GSH-PX,SOD level, SOD in red call and SOD/MDA value were significantly lower than that of 16 normal people( P <0.01).Conclusion: Serum MDA participates in nosogenesis of Nephrotic syndrome,and the decrease of Antioxidation system capability results in Nephrotic syndrome.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第24期47-49,共3页
China Journal of Modern Medicine
