摘要
A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product from β-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.
A novel catalyst indium(Ⅲ) tribromide is shown to efficiently promote 5-carbonyl-4-aryl-3,4-dihydropyrimidin-2(1H)-ones from a three-component coupling of β-diketones, aldehydes and urea in ethanol. This modified one-pot Biginelli′s cyclocondensation not only features simple operation, but also takes place in nonpolluted environment. The structure of the Biginelli reaction product from β-diketones, salicylaldehyde and urea has been proposed to possess an oxygen-bridge.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2003年第1期79-81,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 9872 0 18
2 9972 0 2 6 )
南开大学元素有机国家重点实验室和教育部博士学科点基金 (批准号 :19990 0 5 5 2 0 )资助
