摘要
目的:探讨原发性肺癌中内皮素(Endothelin,ET)表达特征与DNA含量及预后的关系。方法:应用免疫组化方法和图像分析技术,检测了66例不同病理类型肺癌石蜡标本中ET表达和DNA含量,并将所有病例随访至2年以上。分析了ET与病理、临床各因素间的关系。结果:肺癌中ET阳性表达率高达73％,其含量显著高于支气管良性病变(P<0.01),不同组织学类型间无显著性差异(P>0.05)。在ET阳性表达组DNA含量显著高于阴性组(P<0.05),并且分期愈晚、分化愈差、转移范围愈广,ET水平愈高,生存率愈低。结论:肺癌ET与DNA含量有显著正相关关系(P<0.01),提示ET参与诱导肺癌细胞的增殖,可作为判断肺癌预后的一项有价值指标,通过拮抗ET生物学效应可能成为肺癌靶向治疗新途径。
Purpose: To investigate the relationship between the expression of ET, the content of DNA and prognosis in primary lung cancer. Methods: The expressions of ET and the contents of DNA in 66 cancer specimens of different pathological grades were studied by immunohistochemistry and image - analysis technique, all cases were followed up more than 2 years. Results: The positive rate of ET in lung cancer was 73%, which was significantly higher than that in benign bronchial disease (P<0.01), there were no differences between different pathological grades (P>0.05). The content of DNA in the positive group of ET was significantly higher than that in the negative group (P < 0. 05), moreover, if there was a later stage, a lower pathological grade or an extensive metastasis, there would be a higher expression of ET and a lower survival rate. Conclusions: There was a significantly positive correlation between ET of lung cancer and the content of DNA (P<0.01).It is suggested that ET involved in induction of cancer cell progress, was a valuable marker for determining prognosis of lung cancer and may be a new target - therapy of lung cancer through inhibition of ET.
出处
《中国癌症杂志》
CAS
CSCD
2002年第6期500-502,共3页
China Oncology
