摘要
本文观察了氯胺酮对10例大面积烧伤病人休克期后血液动力学的影响。全组病人平均烧伤面积为53.7±14％。静注氯胺酮2mg/kg诱导后以0.2％氯胺酮静滴维持(50μg/kg/min)。观察结果表明渡过休克期的大面积烧伤病人处于高排低阻的高血液动力学状态,其血中肾上腺素、去甲肾上腺素含量明显增高。使用小剂量氯胺酮后,机体仍能进一步增加肾上腺素的释放,心血管系统对增加的肾上腺素亦具有较良好的反应性。
The effects of ketamine on the hemodynamics in the postshock stage in 10 severely burn patients were observed.Their average burn area was 53.7±14% TBSA.Anesthesia was inducedwith 2 mg/kg of ketamine and then maintained with 50μg/kg/minute of ketamine.All the patients kept on spontaneous breathing.Measurements were performed before anesthesia,5 and 30 minutes after the induction of anesthesia.and 20 minutes after the discontinuation of ketamine.Our findings indicate that the severely burn patients in the postshock stage were in a state of active hemodynamics with increased cardiac output and decreased peripheral resistance.The plasma concentrations of epinephrine and norepinephrine were apparently increased.A small dose of ketamine could further increase the release of epinephrine,which is beneficial to the restoration of normal cardiovascular functions.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第3期226-229,共4页
Journal of Third Military Medical University
关键词
氨胺酮
烧伤
血液动力学
休克
ketamine
burns
hemodynamics
shock
traumatic
