摘要
胰腺癌患者血清GPDA活力变化尚乏完整报道。对166例消化道疾病及60例正常对照组血清GPDA测定结果表明,胰腺癌患者血清GPDA活力为101.02±75.84u/L(M±s),显著高于正常对照组。与胰腺炎差异显著(P<0.05)。胰腺癌患者血清GPDA活力增高集中于胰头癌,对胰头癌诊断敏感性为63.63％,并与肿瘤细胞分化程度有关,但是与肿瘤大小无关。此外,血清GPDA活力在胆管壶腹癌及肝癌患者中显著增高,在胃癌患者中显著降低。提示血清GPDA活力测定可作为胰腺癌及部份消化道肿瘤的辅助检查指标之一。
There has been no detailed reiport on the changes of the activity of serum glycylproline dipeptidyl aminopeptidase (GPDA) in patients with pancreatic career.Tn this paper,the serum level of GPDA was measured in 166 cases with various malignant and benign gastrointestinal diseases and 60 normal controls.It was found that the serum GPDA activity in patients with pancreatic cancer was 101,02±75.84u/L and significantly higher than that in the patients with pancreatitis and in the normal controls.There was a statistically significant difference of the GPDA activity value between the patients with malignant and benign pancreatic diseases.The elevation of GPDA activity was more marked in those patients with cancers in the head of the pancreas.In addition,the elevation of GPDA activity was dependent on the differentiation of cancer cells but not on the size of cancers.Significantly higher level of GPDA was also found in patients with hepatic carcinoma and carcinoma of ampulla of vater but significantly lower level in patients with gastric cancer.It is believed that the determination of serum GPDA activity might be helpful for the diagnosis of pancreatic cancer.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1992年第1期35-37,43,共4页
Journal of Third Military Medical University
关键词
组织蛋白酶类
血液
胰腺肿瘤
诊断
cathepsins/BL
pancreatic neoplasms/DI
glycylglycine
