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甲基化与妇科肿瘤的研究进展

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摘要 甲基化是真核细胞DNA正常的修饰方式,但异常甲基化则为肿瘤发生的重要因素。在人类多种妇科肿瘤中都可以发现不同程度的DNA异常甲基化现象。介绍DNA甲基化在基因表达中的作用及其抑制基因转录、表达的机理,DNA异常甲基化与妇科肿瘤发生、演进的关系,甲基化的检测方法以及去甲基化在妇科肿瘤治疗方面的应用前景。
作者 欧春怡
出处 《国外医学(妇产科学分册)》 2002年第6期367-370,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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