摘要
目的分析丁苯酞对急性脑血栓合并抑郁患者的疗效以及患者血浆溶血磷脂酸(LPA的变化。方法选取我院于2015年1月~2018年1月收治的128例急性脑血栓合并抑郁患者作为研究对象,分为2组。对照组在常规治疗基础上口服盐酸舍曲林片治疗,观察组在对照组治疗基础上联合丁苯酞治疗,比较2组患者治疗后的临床疗效。结果 2组患者治疗前LPA、基质金属蛋白酶-9(MMP-9)、血浆血栓性球蛋白(β-TG)、血小板IV因子(PF4)、凝血功能水平组间比较无明显差异(P>0.05)。观察组患者治疗后LPA、MMP-9、β-TG、PF4、APTT、FIB、D-D水平低于对照组,PT水平高于对照组(P<0.05)。2组患者治疗前美国国立卫生研究院卒中量表(NIHSS)、运动功能评定量表(Fugl-Meyer)、Barthel指数评定量表(BI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分无明显差异不(P>0.05)。观察组患者治疗后Fugl-Meyer、BI评分高于对照组,NIHSS、SAS、SDS低于对照组(P<0.05)。结论丁苯酞治疗急性脑血栓合并抑郁患者,可降低LPA水平,改善神经功能缺损情况,减轻焦虑、抑郁症状,提高患者生命质量。
Objective To analyze the effect of butylphthalide on patients with acute cerebral thrombosis complicated with depression and the changes of plasma lysophosphatidic acid(LPA).Methods The clinical data of 128 patients with acute cerebral thrombosis complicated with depression from January 2015 to January 2018 were analyzed and divided into two groups.The control group was treated by oral sertraline hydrochloride on the basis of routine treatment,and the observation group was treated with butyphthalide on the basis of the control group.The clinical efficacy of the two groups was analyzed.Results There was no significant difference in LPA,matrix metalloproteinase-9(MMP-9),plasma thromboglobulin(β-TG),)IV factor(PF4)and coagulation function between the two groups before treatment(P>0.05).The levels of LPA,MMP-9,β-TG,PF4,APTT,FIB,D-D and PT in the observation group were lower than those in the control group(P<0.05).Before treatment,the(NIHSS),of the American National Institutes of Health Stroke scale was higher in the two groups(P<0.05).Motor function rating scale(Fugl-Meyer)There was no significant difference in the(SDS)score of Barthel index rating scale(BI),anxiety self-rating scale(SAS),self-rating depression scale between the two groups(P>0.05).After treatment,the Fugl-Meyer,BI score and NIHSS,SAS,SDS in the observation group were higher than those in the control group(P<0.05).Conclusion Butyphthalide treatment for patients with acute cerebral thrombosis combined with depression can reduce the level of LPA,improve the neurological function defect,relieve anxiety and depression symptoms,and improve the quality of life of the patients.
作者
刘艳芳
王超伟
高伟
孙世辉
LIU Yanfang;WANG Chaowei;GAO Wei(General Hospital of Henan Yimei Company,Yima 472300,China)
出处
《国际精神病学杂志》
2019年第3期524-526,536,共4页
Journal Of International Psychiatry
关键词
丁苯酞
急性脑血栓
溶血磷脂酸
焦虑
抑郁
Butylphthalide
Acute cerebral thrombosis
Lysophosphatidic acid
Anxiety
Depression
