摘要
目的观察女性更年期失眠伴焦虑抑郁患者应用坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片治疗后效果。方法将我院107例女性更年期失眠伴焦虑抑郁患者采用随机数字表法分组,对照组53例予坤泰胶囊,观察组54例联合雌二醇片/雌二醇地屈孕酮片,对比两组患者临床疗效、性激素水平、睡眠质量、负性情绪及安全性。结果观察组总有效率、雌二醇(E2)水平高于对照组,卵泡生成激素(FSH)、黄体生成激素(LH)及匹兹堡睡眠质量指数(PSQI)、症状自评量表(SCL-90)、抑郁自评量表(SDS)、焦虑自测量表(SAS)低于对照组(P<0.05);观察组不良事件发生率高于对照组(P>0.05)。结论坤泰胶囊联合雌二醇片/雌二醇地屈孕酮片能够更有效治疗女性更年期失眠以及伴有的焦虑抑郁情绪。其机制可能与调节性激素水平,改善卵巢功能有关。
Objective To observe the effect of Kuntai Capsule combined with Fentonone in the menopausal women with insomnia,anxiety and depression. Methods 107 women menopausal with insomnia,anxiety and depression were enrolled in our hospital by random number table.53 patients in the control group were given Kuntai capsule,and 54 patients in the observation group were combined with Fentonone. The clinical efficacy,sex hormone level and sleep quality of the two groups were compared. Results The total effective rate and E2 level in the observation group were higher than those in the control group. The FSH,LH and PSQI,SCL-90,SDS and SAS in the observation group were lower than those in the control group(P<0.05). The incidence of adverse events in the observation group was higher than that in the control group(P> 0.05). Conclusion Kuntai Capsule combined with Fenton can effectively eliminate female climacteric insomnia and negative emotions in patients with anxiety and depression,improve sleep quality and symptoms,and its mechanism is related to regulating sex hormone levels,improving ovarian function,and high safety.
作者
张娟
王静芳
张小娟
宋晓婕
ZHANG Juan;WANG Jingfang;ZHANG Xiaojuan(People's Hospital of Queshan County,Zhumadian 463200,China)
出处
《国际精神病学杂志》
2019年第1期147-150,共4页
Journal Of International Psychiatry
