期刊文献+

丙戊酸钠联合利培酮治疗癫痫所致精神障碍的疗效观察 被引量:24

The effect of valproate combined with risperidone in the treatment of epileptic mental disorders
原文传递
导出
摘要 目的探讨丙戊酸钠联合利培酮治疗癫痫所致精神障碍的有效性与安全性。方法将医院2014年1月~2016年12月期间收治的168例癫痫性精神障碍患者作为研究对象,采用简单随机的方法分为对照组与观察组,对照组使用丙戊酸钠联合安慰剂治疗,观察组使用丙戊酸钠联合利培酮治疗。比较两组患者PANSS评分、认知功能、不良反应等,并对临床疗效进行评价。结果治疗后,观察组阳性量表、阴性量表、精神病理和总分均有明显的下降,且明显低于对照组(P<0.05);观察组治疗总有效率90.48%明显高于对照组77.38%(P<0.05);治疗前后,两组患者MMSE评分组间比较均无差异(P>0.05),且治疗后与治疗前相较无显著差异(P>0.05);治疗后,观察组TESS评分为(8.34±2.71),对照组TESS评分为(8.12±2.64)(P>0.05)。结论丙戊酸钠联合利培酮治疗癫痫性精神障碍疗效显著,对患者认知功能影响小,副作用轻,值得推广。 Objective To investigate the efficacy and safety of sodium valproate combined with risperidone in the treatment of epileptic mental disorders. Methods 168 patients with epileptic mental disorder in our hospital from January 2014 to December 2016 were randomly divided into the control group and the observation group. The control group was treated with valproate,and the observation group was treated with valproate plus risperidone. Results After treatment,the positive scale,negative scale,psychopathology and total score of the observation group decreased significantly,and obviously lower than that of the control group(P<0.05). The total effective rate of treatment in the observation group was 90.48% significantly higher than that(77.38%)of the control group(P<0.05). After treatment,the score of TESS in the observation group was(8.34+2.71),and the score of TESS in the control group was(8.12+2.64)(P>0.05). Conclusion Valproate combined with risperidone are effective in the treatment of epileptic mental disorders,with mild side effects and less risk.
作者 白金娟 田龙 张红利 崔凌 BAI Jinjuan;TIAN Long;ZHANG Hongli(Internal Medicine-Neurology,Zhengzhou people's Hospital,Zhengzhou 450000,China)
出处 《国际精神病学杂志》 2019年第1期130-133,共4页 Journal Of International Psychiatry
关键词 丙戊酸钠 利培酮 精神障碍 Valproate Risperidone Psychosis
  • 相关文献

参考文献10

二级参考文献92

共引文献121

同被引文献269

引证文献24

二级引证文献60

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部