摘要
目的 探讨大黄促进肠道运动的机制 ,为临床应用大黄提供理论依据。方法 32只Wistar大鼠随机分为大黄组及对照组 ,分别给大鼠灌服大黄水提液或蒸馏水 1、6h后 ,以葡聚糖蓝 2 0 0 0为胃肠内标记录观察大鼠小肠传输的变化 ,同时用放射免疫分析法测定血浆及空肠组织匀浆中胃动素 (MTL)、P物质 (SP)、血管活性肠肽 (VIP)的含量。结果 灌服大黄水提液后 ,大鼠小肠传输显著增强 (P <0 .0 5或P <0 .0 1) ,血浆、空肠组织匀浆中MTL、SP的含量明显升高 (P <0 .0 5或P <0 .0 1) ,VIP含量明显降低 (P <0 .0 5或P <0 .0 1)。结论 大黄对大鼠小肠运动有明显的促进作用 ,其机制可能与促进肠道MTL及SP的释放和抑制VIP的释放有关。
Aim To study the effect of rheum officinale on intestinal transit and its mechanisms.Methods All 32 Wistar rats were randomly divided into rheum officinale group and control group and then were given rheum officinale decoction or distilled water.After 1 and 6 hours respectively,the intestinal transit of rats were assayed by Dextran blue 2000 as an indicator,the contents of motilin(MTL),substance P(SP)and vasoactive intestinal peptide(VIP)in plasma and jejunal tissue were measured by radioimmunoassay.Results The intestinal transit of rats was markedly enhanced (P<0.01 or P<0.05),the contents of MTL and SP increased significantly and the content of VIP decreased (P<0.01 or P<0.05) in plasma and jejunal tissue at 1,6 hours after rheum officinale decoction was given.Conclusion Rheum officinale can promote intestinal transit in rats.It may be corelated to the increased contents of MTL and SP and decreased content of VIP in plasma and jejunal tissue.
出处
《解放军药学学报》
CAS
2002年第6期339-340,346,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
