摘要
目的:探讨益气活血中药方剂对早期闭塞性动脉硬化症(ASO)的治疗作用。方法:90例ASO患者随机分为2组,治疗2个月,观察2组治疗前后临床表现、血脂、血液流变学、血管内皮细胞功能、血流动力学等的变化。结果:冶疗组临床治愈率为61.67%,总有效率为100％;对照组临床治愈率为36.67％,总有效率为93.33%。对主要症状、体征的疗效,治疗组明显优于对照组(P<0.01)。对血脂的影响,治疗组治疗前后甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)差异有显著性(P<0.01);血清总胆固醇(TC)、极低密度脂蛋白胆固醇(VLDL-C)、载脂蛋白A_1(ApoA_1)、载脂蛋白B_(100)(ApoB_(100))亦有显著差异(P<0.05)。治疗组治疗后血液流变学各项指标较治疗前均明显下降(P<0.01);治疗后治疗组血浆血栓素B_2(TXB _2)、6-酮前列腺素F_(1α)(6-keto-PGF_(1α))恢复至正常(P<0.05),血浆内皮素(ET-1)水平降低,一氧化氮(NO)值增高(P<0.01)。两组的TXB_2及对照组TXB_2、6-keto-PGF_(1α),与正常组相比仍有显著差异(P<0.01)。治疗组治疗后股、腘动脉管腔宽度和血流量有增加,踝/肱指数明显升高(P<0.01)。结论:益气活血方剂黄芪通脉合剂治疗早期ASO能明显改善临床症状,并具有调节血脂代谢、抗血栓形成、保护血管内皮细胞功能等作用。
To explore therapeutic action of the formula for supplementing Qi and activating blood circulation on early arteriosclerosis obliterans (ASO). Methods: 90 cases of ASO were randomly divided into 2 groups and treated for 2 months, and changes of their clinical manifests, blood lipids, hemorheology. vascular endotheliocyte function and hemodynamics were investigated before and after treatment. Results: The clinical cured rate and the total effective rate in the treatment group were 61. 67% and 100% respectively, and 36. 67% and 93. 33% in the control group. The treatment group in therapeutic effect for main symptoms and signs was superior to the control group (P < 0. 01). There were significant differences in triglyceride (TG). high density lipoprotein-cholesterol (HDL-C ), lower density lipoprotein-cholesterol
(LDL-C) (P<0. 01) and serum total cholesterol (TC). very lower density lipoprotein-cholesterol (VLDL-C). apoprotein A1
(ApoA1) and apoprotein B100 (ApoB100) (P<0. 05) before and after treatment. After treatment, the various indexes of hemorheology decreased significantly (P<0. 01). and plasma thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) restored to normal; plasma endothelin (ET-1) level decreased, nitric oxide (NO) increased (P < 0. 05) in the treatment group. TXB2 in the both groups and 6-keto-PGF1αin the control group were significantly different from those of the normal group (P<0. 01). After treatment, in the treatment group the width of lumen and volume of blood flow in the posterior femoral and poplitead arteries increased, and the ankle/ humeral index increased significantly (P<0. 01). Conclusion: Huang Qi Tong Mai Mixture can obviously improve clinical symptoms of early ASO. and also can regulate lipid metabolism, antagonize thrombosis and protect vascular endotheliacyte function.
出处
《中医杂志》
CSCD
北大核心
2002年第12期907-909,共3页
Journal of Traditional Chinese Medicine
关键词
闭塞性动脉硬化
中医药治疗
益气活血法
黄芪通脉合剂
Arteriosclerosis. obliterans/TCM therapy supplementing Qi and activating blood circulation method @Huang Qi Tong Mai Mixture
