摘要
目的比较盐酸羟考酮缓释片与盐酸吗啡缓释片用于控制胰腺癌晚期癌痛的临床疗效及安全性。方法将74例晚期胰腺癌患者分为对照组和试验组,每组37例。对照组予以盐酸吗啡缓释片初始药物剂量为20 mg,q12 h,口服;试验组予以盐酸羟考酮缓释片初始剂量为10 mg,q12 h,口服,3 d后在每次原始药物剂量的基础上增加25%。2组患者均根据患者的疼痛缓解情况对药物剂量进行调整,共治疗15 d。比较2组患者的疼痛控制效果、生活质量(QOL)评分,以及药物不良反的发生情况。结果治疗后,试验组和对照组的总有效率分别为91. 89%(34例/37例)和89. 19%(33例/37例),差异无统计学意义(P> 0. 05)。治疗后,试验组和对照组的QOL评分分别为(18. 90±3. 77)和(16. 62±3. 83)分,差异有统计学意义(P <0. 05)。试验组发生的药物不良反应有恶心呕吐、便秘、口干和瘙痒,对照组发生的药物不良反应有便秘、恶心呕吐、口干和瘙痒。试验组和对照组的总药物不良反应发生率分别为21. 62%和45. 95%,差异有统计学意义(P <0. 05)。结论盐酸羟考酮缓释片与盐酸吗啡缓释片控制胰腺癌晚期癌痛的镇痛效果相当,但是前者能显著改善患者的生存质量,且安全性更好。
Objective To compare the clinical efficacy and safety of oxycodone hydrochloride sustained-release tablets and morphine hydrochloride sustained-release tablets in the control of advanced cancer pain with pancreatic cancer.Methods Seventy-four patients with advanced pancreatic cancer were divided into control and treatment groups with 37 cases per group.Control group was given morphine hydrochloride sustained release tablets at the initial dose of 20 mg,q12 h,oral administration.Treatment group received the initial dose of oxycodone hydrochloride sustained release tablets was 10 mg,q12 h,and increased by 25%on the basis of each original drug dose after 3 days of treatment.The dosage of the drug was adjusted according to the pain relief of the patients in two groups and treated for 15 days.The pain control effect,quality of life score(QOL)and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates of treatment and control groups were 91.89%(34 cases/37 cases)and 89.19%(33 cases/37 cases)without significant difference(P>0.05).Aftertreatment,the QOL scores of treatment and control groups were(18.90±3.77)and(16.62±3.83)with significant difference(P<0.05).The adverse drug reactions of treatment group were nausea and vomiting,constipation,dry mouth and pruritus,while those in the control group were constipation,nausea and vomiting,dry mouth and pruritus.The total incidences of adverse drug reactions in the treatment and control groups were 21.62%and 45.95%with significant difference(P<0.05).Conclusion The analgesic effect of oxycodone hydrochloride sustained release tablets is similar to that of morphine hydrochloride sustained release tablets in the control of advanced pancreatic cancer pain,but the former can significantly improve the quality of life of patients,and the safety is better.
作者
汪业铭
李树铁
高艳
赵继波
李媛莉
冯腾尘
WANG Ye-ming;LI Shu-tie;GAO Yan;ZHAO Ji-bo;LI Yuan-li;FENG Teng-chen(Department of Anesthesiology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China;Department of Critical Care Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,Hebei Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2019年第19期2265-2267,2284,共4页
The Chinese Journal of Clinical Pharmacology
基金
河北省医学科学研究重点课题计划资助项目(20170774)
关键词
盐酸羟考酮缓释片
盐酸吗啡缓释片
胰腺癌
晚期癌痛
安全性评价
oxycodone hydrochloride sustained-release tablet
morphine hydrochloride sustained-release tablet
pancreatic cancer
advanced cancer pain
safety evaluation
