摘要
目的观察p53蛋白和survivin蛋白表达对直肠癌分级和预后影响分析。方法采用免疫组化法检测60例直肠癌组织和30例正常直肠组织中p53蛋白和survivin蛋白表达水平,并比较其表达水平和直肠癌分级和预后之间的关系。结果直肠癌组织中p53蛋白和survivin蛋白表达率均显著上升。低分化的癌组织中survivin表达水平显著高于高分化组织(P<0.05)。T_1~T_2分级和长生存期的癌组织中p53表达水平显著低于T_3~T_4分级和短生存期的癌组织(P<0.05);survivin和p53表达水平无相关性(P>0.05)。结论 p53蛋白和survivin蛋白高表达可作为直肠癌发生及预后的判别指标之一。
Objective To investigate the effect of p53 mutation protein and survivin protein expression on the classification and prognosis of rectal cancer. Methods The expression of p53 protein and survivin protein was detected by immunohistochemistry in 60 cases of rectal cancer tissues and 30 cases of normal rectal tissues. Results The expression rate of p53 protein and survivin protein in rectal cancer tissue was significantly increased,and there was a significant lower expression of Survivin in welldifferentiated cancer tissues(P<0.05). There was a significant lower expression of p53 in T_1-T_2 grades and shorter survival period patients(P<0.05). There was no correlation between Survivin and p53 expression(P>0.05). Conclusion The mutation of p53 protein and over expression of survivin protein are one of the an effective indicators for the occurrence and prognosis of rectal cancer.
出处
《解剖学研究》
CAS
2017年第5期386-389,共4页
Anatomy Research
