摘要
目的 研究运动对早龄OLETF大鼠血糖和血脂的影响。方法 对 40只原发 2型糖尿病模型 -OLETF大鼠和 15只先天不发生 2型糖尿病的LETO大鼠进行运动干预 ,9周后进行血糖和血脂各项指标检测。结果 OLETF、LETO大鼠基础饲料运动组及OLETF大鼠高脂饲料运动组其血浆胆固醇 (TC)、低密度脂蛋白 (LDL)浓度与它们相应的非运动对照组相比 ,均有极显著降低 (P <0 .0 1) ;OLETF、LETO基础饲料运动组大鼠血浆甘油三酯 (TG)浓度较与它们各组的非运动对照组相比也有明显降低 (P <0 .0 5 ) ;OLETF基础饲料运动组和高脂饲料运动组大鼠与它们各自非运动对照组的空腹血糖水平相比 ,虽有下降的趋势 ,但无显著差异。结论 运动可以显著降低OLETF大鼠血浆胆固醇、甘油三酯及低密度脂蛋白水平。运动能够有效预防OLETF大鼠出现脂质代谢紊乱。
Objective To investigate the effect of exe rcise on young OLETF rats′glucose and lipid metabolism. Methods OLETF rat is a spontaneously diabetic animal model and LETO rat is OLETF′s non- diabetic control model. 40 OLETF rats were divided into 4 groups: group A, standard diet plus no exercise; group B, standard diet plus exercise; group C, fat diet plus no exercise; group D, fat diet plus exercise. 15 LETO rat s were allocated into group E (standard diet plus no exercise) and group F (stan dard diet plus exercise). After 9 weeks of exercise intervention, the plasma lev els of glucose and lipid were assessed by means of an autobiochemistry instrumen t in all rats. Results The serum levels of total chol esterol (TC) and low density lipoprotein (LDL) in the three exercise groups were significantly lower than those of the non- exercise control groups( P <0.01 ); the circulating concentration of TC in the exercise OLETF and LETO rats fed by standard diet decreased significantly in comparison with the non- exercise c ontrol groups( P <0.05); A tendency of decrease of plasma levels of glucose was showed in all of the three exercise groups as compared with the non- exerci se control groups, although not significant ( P>0.05 ). Conclus ion Exercise and diet control can significantly decrease the plasma level of total cholesterol and total glycosides and LDL in OLETF rats and effect ively correct the disorder of OLETF rats′fat metabolism.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2002年第9期536-538,共3页
Chinese Journal of Physical Medicine and Rehabilitation
基金
国家自然科学基金资助项目 (No .39970 841 )
美国中华医学基金 (CMB)资助项目 (No .98- 676)
