摘要
目的 应用自制的声学造影剂 ,建立谐波能量多普勒间歇触发显像技术 (ITI)定量节段心肌血流量的完整方法 ,并评价该技术定量心肌血流 (MBF)的准确性和可行性。方法 取 6条开胸犬 ,显示乳头肌中部水平短轴切面 ,静脉连续滴注造影剂 ,分别在基础状态、静脉给予潘生丁造成的充血状态及充血状态下左冠状动脉回旋支 (LCx)不同程度狭窄状态进行心肌造影超声心动图 ,将左室壁分成前壁、侧壁、后壁、下壁、后间隔和前间隔 6个节段分析。在最后狭窄状态 ,于心肌声学造影 (MCE)结束后左房内注入放射性微球 (MIC)测量MBF ,并与ITI测值进行对比。结果 在各节段显像中 ,位于聚焦区附近的前间隔和后壁的显像成功率最高 ,均为 88% ( 2 9/ 3 3 ) ,位于近场的侧壁显像成功率最低 ,为 61% ( 2 0 / 3 3 )。标准化后ITI测量的后壁 /前壁、后壁 /侧壁及后壁 /前间隔的MBF比值与MIC测值相关 ,其中以后壁 /前间隔的相关性最强(r =0 .97,P <0 .0 0 1)。非缺血区ITI测得的MBF绝对值 (前壁、下壁、后间隔和前间隔 )和MBF比值 (前间隔 /前壁、前间隔 /下壁、前间隔 /后间隔 )与MIC测值相关有显著性 ,但相关性较差 (r =0 .5 2 ,P =0 .0 1和r =0 .44 ,P =0 .0 1)。在缺血区 (后壁和侧壁 ) ,ITI测得的MBF绝对值和MBF比值 (前间隔
Objective To establish the intergrate method of quantifying regional myocardial blood flow (MBF) by intermittent triggered imaging (ITI), and assess its feasibility and accuracy. Methods Self made agent and AGILENT SONOS 5500 echocardiographic system were used for ITI in 6 open chest dogs at baseline, during hyperemia with dipyridamole (DIP) and in different severity of LCx stenosis. The left ventricle was imaged on short axis view at mid papillary muscle level, and assigned to 6 segments: anterior, lateral, posterior, inferior, posteroseptal, and anteroseptal. MBF was calculated by multiplying the rate of replenishment and the plateau of myocardial video intensity. At the last stenosis level, radiolabeled microspheres were injected into left atrium after MCE for comparison. Results The feasibility of ITI was the highest in anterior septum and posterior wall, which were both 88%(29/33), but was the lowest in lateral wall, which was only 61%(20/33). The MBF ratio in posterior/ anterior, posterior/lateral and posterior/anterior septum evaluated by ITI correlated well with MIC MBF, with the most excellent in posterior/anterior septum ( r =0.97, P <0.001). The MBF absolute values and MBF ratios evaluated by ITI in nonischemic regions (anterior, inferior, posterior septum and anterior septum) (anterior septum/anterior, anterior septum/inferior and anterior septum/posterior septum) had poor correlations with MIC ( r =0.52, P = 0.01 and r =0.44, P =0.01). However, the MBF absolute values and the MBF ratios measured by ITI in ischemic regions (posterior and laterior) (anterior septum/laterior and anterior septum/posterior) correlated well with MIC ( r =0.75, P = 0.01 and r =0.78, P =0.003). Conclusion The feasibility of ITI MBF is high in the anterior septum and posterior wall of left ventricle. After normalized the value by MBF ratio, ITI MBF in posterior/anterior, posterior/lateral and posterior/anterior septum correlated well with MIC MBF.
出处
《中国医学影像技术》
CSCD
2002年第12期1217-1220,共4页
Chinese Journal of Medical Imaging Technology
关键词
可行性
准确性
谐波能量多普勒
间歇触发显像
心肌造影超声心动图
心肌血流量
Harmonic power Doppler
Intermittent triggered imaging
Myocardial contrast echocardiography
Quantification
Myocardial blood flow
