摘要
目的:探讨老年2型糖尿病(T2DM)患者微血管并发症(MC)发生的影响因素,构建并评价列线图预测模型的预测效能。方法:317例T2DM患者根据是否发生MC分为未发生组(n=221)和发生组(n=96)。采用多因素Logistic回归模型分析影响因素,基于影响因素构建列线图预测模型。采用受试者工作特征(ROC)曲线分析预测价值。结果:年龄偏大、病程长、高空腹血糖(FPG)、高糖化血红蛋白(HbA1c)、低高密度脂蛋白胆固醇(HDL-C)、高低密度脂蛋白胆固醇(LDL-C)水平为老年T2DM患者发生MC的独立危险因素(P<0.05)。年龄、病程、FPG、HbA1c、HDL-C、LDL-C及列线图预测模型的曲线下面积(AUC)分别为0.799、0.769、0.649、0.704、0.678、0.705、0.950。结论:老年T2DM发生MC与年龄、病程、FPG、HbA1c、HDL-C、LDL-C密切相关。基于上述影响因素构建的列线图预测模型可以有效预测老年T2DM患者发生MC的风险。
Objective:To explore the influencing factors of microvascular complications(MC)in elderly type 2 diabetes mellitus(T2DM)patients,and to construct and evaluate the predictive efficacy of the nomogram prediction model.Methods:317 T2DM patients were divided into non-occurrence group(n=221)and occurrence group(n=96)according to whether MC occurred.The influencing factors was analyzed by multivariate Logistic regression models,a nomogram prediction model was constructed based on the influencing factors.The predictive value was analyzed by receiver operating characteristic(ROC)curve.Results:Older age,longer course of disease,High fasting blood glucose(FPG),high glycated hemoglobin(HbA1c),low high-density lipoprotein cholesterol(HDL-C),high low-density lipoprotein cholesterol(LDL-C)levels were independent risk factors for MC in elderly T2DM patients(P<0.05).The area under the curve(AUC)of age,course of disease,FPG,HbA1c,HDL-C,LDL-C and nomogram prediction model were 0.799,0.769,0.649,0.704,0.678,0.705 and 0.950 respectively.Conclusion:The MC occurs in elderly T2DM patients are closely relate to age,course of disease,FPG,HbA1c,HDL-C and LDL-C.The nomogram prediction model based on the above influencing factors can effectively predict the risk of MC in elderly T2DM patients.
作者
朱慧娟
谢先龙
肖庭怡
柯钰雅
吴艳霞
ZHU Hui-juan;XIE Xian-long;XIAO Ting-yi;KE Yu-ya;WU Yan-xia(Department of General Medicine,Wuhan Integrated Traditional Chinese and Western Medicine Hospital(Wuhan First Hospital),Wuhan,Hubei,430022,China)
出处
《现代生物医学进展》
CAS
2024年第22期4281-4284,共4页
Progress in Modern Biomedicine
基金
湖北省卫生健康委员会科研项目(WJ2018F038)。
关键词
2型糖尿病
老年
微血管并发症
危险因素
预测价值
Type 2 diabetes mellitus
Elderly
Microvascular complications
Influencing factors
Predictive value
