摘要
目的探讨银杏内酯注射液辅助治疗对老年急性脑梗死(ACI)的疗效。方法选取2020年1月至2023年1月在海安市中医院收治的86例ACI患者作为研究对象,采用1∶1简单随机数字表法将患者分为两组,对照组(43例)予以口服阿司匹林、硫酸氢氯吡格雷常规治疗,观察组(43例)在对照组基础上增加银杏内酯注射液辅助治疗,均治疗14 d。比较两组临床疗效和治疗前后血管内皮功能[内皮素(ET-1)水平、一氧化氮(NO)]、血液流变学[全血黏度(WBV)、纤维蛋白原(FIB)和血浆黏度(PV)]、神经功能[神经功能缺损评分(NIHSS)、改良Rankin量表(mRS)],记录不良反应。结果观察组与对照组总有效率分别为95.35%、79.07%,差异有统计学意义(χ^(2)=5.108,P=0.024)。观察组治疗后血清ET-1、全血WBV、FIB、PV、NIHSS评分、mRS评分[分别为(72.36±7.75)ng·L^(-1)、(2.14±0.41)mPa·s、(4.66±1.61)g·L^(-1)、(1.65±0.53)mPa·s、(2.04±0.45)分、(1.05±0.27)分]低于对照组[分别为(80.17±7.92)ng·L^(-1)、(3.98±0.85)mPa·s、(5.78±1.79)g·L^(-1)、(2.94±0.65)mPa·s、(2.53±0.57)分、(1.49±0.34)分],差异均有统计学意义(均P<0.05);两组治疗后血清NO比治疗前明显升高,观察组(41.08±4.94)μmo·L^(-1),高于对照组(36.77±3.88)μmo·L^(-1),差异有统计学意义(P<0.05)。两组ACI患者治疗期间不良反应对比,差异无统计学意义(9.30%vs 6.98%,χ^(2)=0.156,P=0.693)。结论银杏内酯注射液辅助治疗可以提高ACI患者临床疗效,改善血液流变学、血管内皮与神经功能。
Objective To explore the curative efficacy of ginkgolide injection for adjuvant therapy of acute cerebral infarction(ACI)in elderly patients.Methods A total of 86 patients with ACI admitted to Hai’an Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were enrolled as the research objects.According to the random number table method,these patients were divided into the control group(n=43,routine treatments:oral aspirin and clopidogrel bisulfate)and the observation group(n=43,ginkgolide injection in addition to the regimen in the control group).All the patients in both groups were treated for 14 days.The clinical curative effect,vascular endothelial function(endothelin(ET-1),nitric oxide(NO)),hemorheology(whole blood viscosity(WBV),fibrinogen(FIB),plasma viscosity(PV))and nerve function(national institute of health stroke scale(NIHSS),modified Rankin scale(mRS))before and after treatment were compared betweend the two groups.The adverse reactions were also recorded.Results There were significant differences in total response rate between observation group and control group(95.35%vs 79.07%,χ^(2)=5.108,P=0.024).After treatment,levels of serum ET-1,WBV,FIB and PV,scores of NIHSS and mRS were decreased in both groups,and they were lower in the observation group(P<0.05),while level of serum NO was significantly increased,which was higher in the observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and control group during treatment(9.30%vs 6.98%,χ^(2)=0.156,P=0.693).Conclusion Ginkgolide injection for adjuvant therapy can improve clinical curative effect,hemorheology,vascular endothelial function and nerve function in patients with ACI.
作者
何春慧
戴其军
陈军
He Chun-hui;Dai Qi-jun;Chen Jun(Department of Pharmacy,Hai’an Hospital of Traditional Chinese Medicine(Hai’an Hospital Affiliated to Hanlin College of Nanjing University of Traditional Chinese Medicine),Hai’an 226600,China;Department of Neurology,Hai’an Clinical School,Medical College of Yangzhou University,Hai’an 226600,China;Department of Rehabilitation,Hai’an Clinical School,Medical College of Yangzhou University,Hai’an 226600,China)
出处
《中国药物应用与监测》
CAS
2024年第6期725-728,共4页
Chinese Journal of Drug Application and Monitoring
基金
江苏省中药骨干人才高级研修项目(苏中医科教[2022]17号)
南通市基础科学研究和社会民生科技计划项目(MSZ2022068)
南通市药学会常州四药医院药学科研基金项目(ntyx2206)。
关键词
急性脑梗死
银杏内酯注射液
神经功能
改良Rankin评分
内皮功能
Acute cerebral infarction
Ginkgolide injection
Nerve function
Score of modified Rankin scale
Endothelial function
