摘要
目的:探讨岩藻多糖的生物学活性以及对胃肠道疾病的作用,为研发预防和辅助治疗胃肠道疾病且具有较低毒副作用的岩藻多糖功能食品、保健品和药物提供科学依据。方法:以岩藻多糖、褐藻多糖硫酸脂、褐藻糖胶、保护胃粘膜、调节肠道菌群、幽门螺杆菌、纳米颗粒为检索词在国内外数据库查找相关文献并归纳及总结。结果:岩藻多糖具有阻止幽门螺杆菌粘附胃黏膜、减少幽门螺杆菌生物被膜的形成、抑制幽门螺杆菌的入侵及感染作用,是一种清除体内幽门螺杆菌、保护胃黏膜、辅助治疗胃部疾病的新型制剂。岩藻多糖对胃肠道的保护作用表现在通过修复胃肠道的理化屏障、增强免疫屏障功能、调节微生物屏障等方面。结论:岩藻多糖对胃肠道疾病起到保护剂、调节剂以及胃肠道免疫作用,可作为胃癌肠癌患者的膳食补充剂,帮助患者缓解治疗的副作用,控制减缓疾病发展转归作用。
【Objective】To investigate the biological activity of fucoidan and its effects on gastrointestinal diseases to provide scientific support for the research and development of functional food,health products and drugs with low toxic side effects for the prevention and adjuvant treatment of gastrointestinal diseases.【Method】Relevant literature was retrieved and summarized from domestic and international databases using keywords such as fucoidan,sulfated fucans,alginate,gastric mucosal protection,gut microbiota regulation,Helicobacter pylori,and nanoparticles.【Result】Fucoidan has the ability to prevent Helicobacter pylori from adhering to the gastric mucosa,reduce the formation of Helicobacter pylori biofilms,and inhibit the invasion and infection of Helicobacter pylori.It serves as a novel preparation for eradicating Helicobacter pylori,protecting the gastric mucosa,and assisting in the treatment of gastric diseases.The protective effects of fucoidan on the gastrointestinal tract are achieved through the repair of the physicochemical barrier of the gastrointestinal tract,enhancement of immune barrier functions,and regulation of the microbial barrier.【Conclusion】Fucoidan plays a protective,modulator and immune role in gastrointestinal diseases,and can be used as a dietary supplement for patients with gastric and intestinal cancer to help patients alleviate the side effects of treatment and control the outcome of slowing down the development of diseases.
作者
尚伟华
刘剑英
王发合
邱霞
SHANG Wei-hua;LIU Jian-ying;WANG Fa-he;QIU Xia(Qingdao Special Servicemen Recuperation Center of PLA Navy,Qingdao 266071,China;Qingdao Brightmoon Ocean Chinese Medicine Technology Co.,Ltd.,Qingdao 266400,China;State Key Laboratory of Marine Food Processing&Safety Control,Qingdao Brightmoon Seaweed Group Co.,Ltd.,Qingdao 266400,China)
出处
《中国食物与营养》
2024年第11期65-69,共5页
Food and Nutrition in China
基金
青岛市医药卫生科研计划项目(项目编号:WJZD229)
青岛市科技计划园区培育计划项目(项目编号23-1-5-yqpy-9-qy)
海藻活性物质国家重点实验室开放基金(项目编号:SKL—BMSG-2022-07)。
关键词
岩藻多糖
胃肠道疾病
幽门螺杆菌
纳米颗粒
fucoidan
gastrointestinal disease
Helicobacter pylori
nanoparticle
