摘要
目的研究超声造影定量参数联合甲胎蛋白(AFP)、磷脂酰肌醇蛋白聚糖3(GPC3)预测肝硬化背景下肝癌发生的价值。方法回顾性选取2021年1月至2023年12月河北省唐山市开滦总医院收治的91例肝硬化患者作为对照组,另选择27例肝硬化合并肝癌患者作为研究组,比较2组AFP、GPC3以及超声造影定量参数,绘制受试者工作特征曲线(ROC)分析超声造影定量参数联合AFP、GPC3预测肝硬化背景下肝癌发生的价值。结果研究组廓清时间、增强时间、达峰时间均低于对照组,但峰值强度高于对照组,差异有统计学意义(P<0.05)。研究组AFP、GPC3均高于对照组,差异有统计学意义(P<0.05)。ROC曲线图显示,各指标预测肝硬化背景下肝癌发生的AUC分别是0.889、0.957、0.805、0.535、0.737、0.704,但联合预测的AUC为0.981(95%CI:0.950~1.000),显著高于单一指标(P<0.05)。结论超声造影定量参数联合AFP、GPC3在预测肝硬化背景下肝癌发生上具有重要作用,值得临床推广使用。
Objective To study the value of quantitative ultrasonography parameters combined with alpha-fetoprotein(AFP)and phosphatidylinositol proteoglycan 3(GPC3)in predicting hepatocarcinogenesis in the context of liver cirrhosis.Methods Ninety-one patients with cirrhosis included in Kailuan general hospital from January 2021 to December 2023 were retrospectively selected as the control group,and another 27 patients with cirrhosis combined with hepatocellular carcinoma were selected as the study group,and the clinical data,AFP,GPC3,and ultrasonographic quantitative parameters of the two groups were compared,and the subjects'work characteristic curves(ROC)were plotted to analyze ultrasonographic quantitative parameters The value of combined AFP and GPC3 in predicting hepatocarcinogenesis in the context of cirrhosis.Results Contour time,enhancement time,and time to peak were lower in the study group than in the control group,but peak intensity was higher in the study group compared with the control group(P<0.05).AFP and GPC3 were higher in the study group than in the control group(P<0.05).From the ROC graph,it was found that the AUC of each index for predicting hepatocarcinogenesis in the context of cirrhosis was 0.889,0.957,0.805,0.535,0.737,0.704,respectively,but the combined prediction reached 0.981(95%CI:0.950-1.000),which was significantly higher than that of a single index(P<0.05).Conclusion Ultrasonography quantitative parameters combined with AFP and GPC3 have an important role in predicting hepatocarcinogenesis in the background of liver cirrhosis,which is worth to popularize its use in clinical practice.
作者
郝玉静
孟妍钰
张丽
李晶晶
陈磊
张冬艳
HAO Yujing;MENG Yanyu;ZHANG Li;LI Jingjing;CHEN Lei;ZHANG Dongyan(Ultrasound Medicine Department,Kailuan General Hospital,Tangshan,Hebei 063000,China)
出处
《转化医学杂志》
2024年第6期868-872,共5页
Translational Medicine Journal
基金
河北省2019年度医学科学研究课题项目(20191338)。
关键词
甲胎蛋白
肝硬化
超声造影
肝癌
磷脂酰肌醇蛋白聚糖3
AFP
Cirrhosis
Ultrasonography
Hepatocellular carcinoma
Phosphatidylinositol proteoglycan 3
