摘要
目的分析甲硝唑片联合克林霉素磷酸酯阴道凝胶治疗细菌性阴道炎的效果。方法选取60例细菌性阴道炎患者作为研究对象,采用随机数字表法将其分为对照组和观察组,各30例。对照组接受克林霉素磷酸酯阴道凝胶治疗,观察组接受甲硝唑片联合克林霉素磷酸酯阴道凝胶治疗。比较两组患者治疗效果、症状消失时间、症状积分、炎性因子指标、阴道免疫细胞指标、复发率、不良反应发生率。结果观察组治疗总有效率93.33%高于对照组的66.67%,差异有统计学意义(P<0.05)。观察组阴道疼痛、外阴瘙痒、白带减少消失时间分别为(3.11±0.25)、(3.65±0.25)、(4.05±0.25)d,均短于对照组的(5.21±0.21)、(5.68±0.12)、(6.68±0.34)d,差异有统计学意义(P<0.05)。治疗后,两组患者症状积分均低于本组治疗前,且观察组症状积分(9.54±1.21)分低于对照组的(12.68±1.24)分,差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6(IL-6)、白细胞介素-4(IL-4)、C反应蛋白(CRP)分别为(51.28±1.21)pg/ml、(62.35±1.65)ng/ml、(2.51±0.35)mg/dl,低于对照组的(70.54±1.23)pg/ml、(86.54±1.52)ng/ml、(3.98±0.42)mg/dl,差异有统计学意义(P<0.05)。治疗后,观察组γ干扰素(IFN-γ)(65.25±1.21)pg/ml、白细胞介素-12(IL-12)(200.51±10.65)pg/ml均低于对照组的(74.69±1.65)、(220.25±6.38)pg/ml,差异有统计学意义(P<0.05)。随访3个月,观察组复发率3.33%低于对照组的30.00%,差异有统计学意义(P<0.05)。观察组不良反应发生率6.67%略低于对照组的10.00%,但无明显差异(P>0.05)。结论临床治疗细菌性阴道炎可在克林霉素磷酸酯阴道凝胶基础上联用甲硝唑片,能更好地控制机体炎性反应,提升阴道免疫细胞功能,促进症状缓解,疗效理想,且能进一步降低疾病复发几率。
Objective To analyze the effect of metronidazole tablets combined with clindamycin phosphate vaginal gel on bacterial vaginitis.Methods 60 cases of bacterial vaginitis patients were selected as the study subjects,and they were divided into the control group and the observation group using the random numerical table,with 30 cases in each group.The control group received clindamycin phosphate vaginal gel treatment,and the observation group received metronidazole tablets combined with clindamycin phosphate vaginal gel treatment.The treatment effect,symptom disappearance time,symptom score,inflammatory factors,vaginal immune cell indicators,recurrence rate,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of 93.33%in the observation group was higher than 66.67%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of vaginal pain,vulvar pruritus and leukorrhea reduction were(3.11±0.25),(3.65±0.25)and(4.05±0.25)d in the observation group,which were shorter than(5.21±0.21),(5.68±0.12)and(6.68±0.34)d in the control group.The difference was statistically significant(P<0.05).After treatment,the symptom scores in both groups were lower than those before treatment in this group,and the symptom score of(9.54±1.21)points in the observation group was lower than(12.68±1.24)points in the control group.The difference was statistically significant(P<0.05).After treatment,interleukin-6(IL-6),interleukin-4(IL-4),and C-reactive protein(CRP)of the observation group were(51.28±1.21)pg/ml,(62.35±1.65)ng/ml,and(2.51±0.35)mg/dl,which were lower than(70.54±1.23)pg/ml,(86.54±1.52)ng/ml,and(3.98±0.42)mg/dl in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group hadγ-interferon(IFN-γ)of(65.25±1.21)pg/ml and interleukin-12(IL-12)of(200.51±10.65)pg/ml,which were lower than(74.69±1.65)and(220.25±6.38)pg/ml in the control group,and the difference was statistically sign
作者
刘娟
范芳
汤吉琴
LIU Juan;FAN Fang;TANG Ji-qin(Department of Obstetrics and Gynecology,Linchuan District People's Hospital,Fuzhou 344000,China)
出处
《中国实用医药》
2024年第23期30-34,共5页
China Practical Medicine
关键词
细菌性阴道炎
克林霉素磷酸酯阴道凝胶
甲硝唑片
炎性反应
免疫细胞功能
复发
Bacterial vaginitis
Clindamycin phosphate vaginal gel
Metronidazole tablets
Inflammatory reaction
Immune cell function
Recurrence
