摘要
目的探讨中西医结合慢性肾脏病(chronic kidney disease,CKD)管理对CKD 3~5期非透析患者的临床效果。方法选取2022年2月至12月在宁波市中医院肾病科就诊的158例CKD 3~5期非透析患者作为研究对象,采用随机数字表法分为对照组和试验组,每组79例。对照组进行常规CKD门诊管理,试验组进行CKD中西医结合管理。比较两组患者随访前后的血尿酸、胆固醇、白蛋白、主观量表评分变化及组间差异,比较两组患者的高钾血症、高磷酸盐血症、贫血、肾功能进展的发生率。结果试验组患者随访1年后的血尿酸、胆固醇水平均低于随访前,且试验组患者的血尿酸低于对照组(P<0.05);试验组患者的高钾血症、高磷酸盐血症、贫血、肾功能进展的发生率均少于对照组(P<0.05);试验组患者的肾脏知识调查评分、健康状况调查简表(36-item short—form,SF-36)评分高于对照组,中医证候总积分低于对照组(P<0.05)。结论中西医结合CKD管理在CKD 3~5期非透析患者中应用效果显著,可有效降低CKD进展的危险因素,控制并发症,延缓肾功能进展,提高患者的生活质量。
Objective To explore the clinical effect of integrative medicine in the management of non-dialysis patients with stage 3-5 chronic kidney disease(CKD).Methods A total of 158 cases of non-dialysis patients with CKD3-5 treated in the Nephrology Department of Ningbo Municipal Hospital of Traditional Chinese Medicine from February to December 2022 were retrospectively collected,and be randomly divided into control group and test group,with 79 cases in each group.Control group underwent regular CKD outpatient management,test group underwent CKD integrative medicine management.Compare changes in blood uric acid,cholesterol,albumin,and subjective scale scores in two groups of patients before and after follow-up,as well as inter-group differences.Compare incidence of hyperkalemia,hyperphosphatemia,anemia,and renal function progression between two groups of patients.Results Blood uric acid and cholesterol levels in test group after 1 year’s follow-up were lower than those before follow-up,and blood uric acid in test group was lower than that in control group(P<0.05).The incidence of hyperkalemia,hyperphosphatemia,anemia,and renal function progression in test group were lower than those in control group(P<0.05).Kidney disease knowledge survey score and 36-item short—form(SF-36)total score of test group were higher than those of control group,and total scores of traditional Chinese medicine syndrome was smaller than that of control group(P<0.05).Conclusion The application of integrative medicine in the management of non-dialysis patients with CKD3-5 has a significant effect,which could effectively reduce risk factors for CKD progression,controll complications,delay renal function progression,and improve the quality of life for patients.
作者
谢文佳
倪佳宁
周舒燕
章婷婷
蔡旭东
XIE Wenjia;NI Jianing;ZHOU Shuyan;ZHANG Tingting;CAI Xudong(Department of Nephrology,Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM),Affiliated of Zhejiang Chinese Medicial University,Ningbo 315000,Zhejiang,China)
出处
《中国现代医生》
2024年第35期17-20,28,共5页
China Modern Doctor
基金
浙江省宁波市科技计划项目(2022S083,2021S167)
浙江省宁波市医学科技计划项目(2020Y16)
浙江省中医药科技计划项目(2024ZL873)
宁波市中西医结合肾病学重点学科立项资助(2022-Z02)。
关键词
中西医结合
慢病管理
CKD3~5期
Integrative medicine
Chronic disease management
Stage 3-5 chronic kidney disease
