摘要
目的检测癫痫患者的血清神经元特异性烯醇化酶(NSE)水平,并分析其与脑电图(EEG)特征的相关性,以及癫痫复发风险的预测因素。方法选取2021年1月—2023年2月湖州市第一人民医院收治的95例癫痫患者作为研究组,同期选择30例体检健康者作为对照组。采用酶联免疫吸附法检测血清NSE水平,采用Kendall分析血清NSE水平与EEG的相关性;随访1年,根据研究组内癫痫患者是否再次发作分为无复发组(41例)和复发组(52例),采用多因素logistic回归分析癫痫患者复发的影响因素。结果研究组血清NSE、甘丙肽(GAL)及肿瘤坏死因子-α(TNF-α)水平均高于对照组(P<0.05);不同EEG异常组血清NSE、GAL及TNF-α水平比较差异均有统计学意义(P<0.05)。Kendall相关系数分析显示,NSE、GAL及TNF-α与EEG特征(异常程度)呈正相关关系(P<0.05)。复发组与无复发组抗癫痫药物服药种数、血清NSE、GAL及TNF-α水平比较差异均有统计学意义(P<0.05)。多因素logistic回归分析显示:NSE(OR=1.259)及TNF-α(OR=1.097)水平高是癫痫患者复发的独立危险因素(P<0.05)。ROC曲线结果显示:NSE预测癫痫患者复发的AUC为0.859(95%CI:0.786~0.932),TNF-α的AUC为0.703(95%CI:0.594~0.811)。结论血清NSE水平越高,癫痫患者EEG异常程度越高;血清NSE水平对癫痫患者复发风险具有较高的预测价值,可作为癫痫患者复发的独立预测指标。
Objective To detect the level of serum neuron-specific enolase(NSE)in patients with epilepsy,and analyze their correlation with electroencephalogram(EEG)characteristics,as well as identify predictive factors for epilepsy recurrence.Methods A total of 95 epileptic patients admitted to Huzhou First People's Hospital from January 2021 to February 2023 were selected as the research group and 30 healthy people were selected as the control group during the same period.Serum NSE levels were detected by enzyme-linked immunosorbent assay,and the correlation between serum NSE levels and EEG was analyzed by Kendall's correlation.After a one-year follow-up,patients with epilepsy in the research group were divided into a non-recurrence group(n=41)and a recurrence group(n=52).The influencing factors of epilepsy recurrence were analyzed by multivariate logistic regression.Results The levels of serum NSE,galanin(GAL),and TNF-αin the research group were higher than those in the control group(P<0.05).The levels of serum NSE,GAL,and TNF-αin different EEG abnormal groups were significantly different(P<0.05).Kendall's correlation analysis showed positive correlations between NSE,GAL,and TNF-αand the degree of EEG abnormality(P<0.05).The recurrence group showed significant differences in the number of anti-epileptic drugs taken and the levels of serum NSE,GAL,and TNF-αcompared to the non-relapse group(P<0.05).Multivariate logistic regression analysis showed that higher levels of NSE(OR=1.259)and TNF-α(OR=1.097)were independent risk factors for the recurrence of epilepsy(P<0.05).The ROC curve analysis showed that the AUC of 0.859(95%CI:0.786-0.932)for NSE and 0.703(95%CI:0.594-0.811)for TNF-α.Conclusion The higher serum NSE levels are associated with higher EEG abnormalities in epileptic patients.Serum NSE levels have a high predictive value for epileptic recurrence and can serve as an independent predictive index of recurrence risk.
作者
蒋瑞婷
倪琦超
王瑜佳
闵晶晶
JIANG Ruiting;NI Qichao;WANG Yujia;MIN Jingjing(Department of Electroencephalogram Room,Huzhou First People's Hospital,Huzhou,Zhejiang 313000,China)
出处
《中华全科医学》
2024年第12期2100-2103,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2021KY1097)
湖州市公益性应用研究项目(2019GYB06)。
