摘要
白细胞介素24(IL-24)是细胞因子IL-10家族的一员,主要由淋巴细胞和激活的单核细胞产生,通过与膜受体或胞内分子结合激活靶细胞中的Janus蛋白酪氨酸激酶/信号转导与转录激活子(JAK/STAT)、p38丝裂原活化蛋白激酶(p38 MAPK)和内质网应激等途径发挥免疫学功能。IL-24是一种多功能的细胞因子,一方面能够特异地抑制肿瘤的生长和侵袭,加速伤口愈合,发挥心血管保护作用等;另一方面,IL-24参与多种自身免疫性疾病和炎症性疾病的发生,是相关疾病治疗的潜在靶点。本文主要综述了IL-24在机体中的作用和机制,希望为疾病的诊断和治疗提供新的思路与方向。
Interleukin 24(IL-24)is a member of the IL-10 cytokine family and is primarily synthesized by lymphocytes and activated monocytes.IL-24 exerts its immunological functions by interacting with membrane receptors or intracellular proteins,leading to the activation of Janus protein tyrosine kinase/signal transducer and activator of transcription(JAK/STAT),p38 mitogen-activated protein kinase(p38 MAPK),and endoplasmic reticulum stress pathways in target cells.This versatile cytokine has specific abilities to inhibit tumor proliferation and invasion,expedite wound healing,and contribute to cardiovascular protection.IL-24 is involved in the pathogenesis of various autoimmune and inflammatory disorders,presenting itself as a prospective therapeutic target for the treatment of such conditions.This article primarily delves into the role and mechanisms of IL-24 in physiological processes,aiming to provide novel insights and avenues for disease treatment.
作者
朱梦阳
陈文
张涛
肖漓
ZHU Mengyang;CHEN Wen;ZHANG Tao;XIAO Li(Institute of Respiratory and Critical Care Medicine,Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory,the 8th Medical Center of Chinese PLA General Hospital,Beijing 100091;Department of Immunology,School of Basic Medicine,Jiamusi University,Jiamusi 154007;Department of Pathology,the 8th Medical Center of Chinese PLA General Hospital,Beijing 100091,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2024年第11期1024-1028,共5页
Chinese Journal of Cellular and Molecular Immunology
基金
首都卫生发展科研自主创新专项(2022-5-5092)。
