摘要
目的探讨盐酸普拉克索缓释片联合血液透析滤过(HDF)治疗尿毒症(URE)合并不宁腿综合征(RLS)的效果。方法选择2022年5月至2024年1月丰城市人民医院收治的74例URE合并RLS患者,按随机数字表法分为对照组与观察组,各37例。对照组采用HDF治疗,观察组联用盐酸普拉克索缓释片治疗。比较两组国际不宁腿综合征评定量表(IRLS)评分、生化指标、睡眠质量、焦虑程度及不良反应。结果治疗后,观察组IRLS、汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠质量指数量表(PSQI)评分均低于对照组(P<0.05);治疗后,两组尿素氮(BUN)、β_(2)微球蛋白(β_(2)-MG)、甲状旁腺激素(PTH)水平均低于治疗前(P<0.05),但组间对比差异无统计学意义(P>0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论盐酸普拉克索缓释片联合HDF治疗URE合并RLS患者,可缓解RLS病情,有效改善生化指标,缓解焦虑症状,促进睡眠质量提升,且安全有效。
Objective To investigate the effects of pramipexole dihydrochloride sustained-release tablets combined with hemodialysis filtration(HDF)on uremia(URE)complicated with restless leg syndrome(RLS).Methods Selected 74 patients with URE complicated with RLS admitted to Fengcheng People's Hospital from May 2022 to January 2024.Divided into observation group and control group according to the method of random number table,37 cases in each group.The control group underwent HDF,while the observation group was treated with combination therapy of pramipexole dihydrochloride sustained-release tablets.The International Rating Scale for Restless Leg Syndrome(IRLS)scores,biochemical indicators,sleep quality,anxiety level and adverse reactions between the two groups were compared.Results After treatment,the observation group had significantly lower scores on the IRLS,Hamilton Anxiety Scale(HAMA),and Pittsburgh Sleep Quality Index(PSQI)compared to the control group,and the levels of urea nitrogen(BUN),β_(2)-microglobulin(β_(2)-MG),and parathyroid hormone(PTH)in two groups were lower comparing with those before treatment(P<0.05).But there was no statistically significant difference in the comparison between the groups(P>0.05).The adverse reactions of two groups were compared,which showed no statistical difference(P>0.05).Conclusion The combination of pramipexole dihydrochloride sustained-release tablets and HDF in the treatment of patients with URE complicated with RLS can alleviate the condition of RLS,effectively improve biochemical indicators,relieve anxiety symptoms and enhance sleep quality,which is safe and effective.
作者
漆石平
雷卫娟
QI Shi-ping;LEI Wei-juan(Fengcheng People's Hospital,Fengcheng,Jiangxi331100)
出处
《实用中西医结合临床》
2024年第23期41-44,共4页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
关键词
尿毒症
不宁腿综合征
盐酸普拉克索缓释片
血液透析滤过
Uremia
Restless leg syndrome
Pramipexole dihydrochloride sustained-release tablets
Hemodialysis filtration
