摘要
前列腺癌是老年男性最为常见的恶性肿瘤之一,确诊时多属晚期并伴发转移,严重威胁身心健康,影响生活质量。内分泌治疗的目的在于降低雄激素水平以抑制前列腺癌细胞的增殖,是激素敏感性前列腺癌的重要治疗手段,即便在去势抵抗阶段,使用内分泌药物对抗雄激素仍有一定的临床价值。本文综述了前列腺癌内分泌药物治疗的进展,从不同分类阐述内分泌药物的临床应用,及其与手术、放疗、化疗和中医药治疗联合使用的疗效和优势,并提出现阶段存在的一些问题,以期为临床选择内分泌药物提供一些参考。
Prostate cancer is one of the most common malignant tumors in elderly men.When diagnosed,it is often in the late stage and accompanied by metastasis,seriously threatening physical and mental health and affecting quality of life.The purpose of endocrine therapy is to reduce androgen levels to inhibit the proliferation of prostate cancer cells,which is an important treatment for hormone sensitive prostate cancer.Even in the castration resistance stage,the use of endocrine drugs to combat androgens still has certain clinical value.This article reviews the progress of endocrine drug therapy for prostate cancer,elaborating on the clinical application of endocrine drugs from different classifications,as well as the efficacy and advantages of their combination with surgery,radiotherapy,chemotherapy,and traditional Chinese medicine treatment.It also points out some existing problems in the current stage,in order to provide some reference for clinical selection of endocrine drugs.
作者
徐新宇
彭煜
朱文静
XU Xinyu;PENG Yu;ZHU Wenjing(Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,CHN)
出处
《河南大学学报（医学版）》
CAS
2024年第6期391-395,共5页
Journal of Henan University:Medical Science
基金
国家自然科学基金(82174451,81973729)
岳阳医院中医优势专科建设专项[YW(2023-2024)-01-04]。
关键词
前列腺癌
内分泌治疗
化疗
中医药
prostate cancer
endocrine therapy
chemotherapy
traditional Chinese medicine
