摘要
目的:探讨CT引导下的铱-192(192Ir)三维后装放疗在局部晚期宫颈癌患者中的近期疗效及安全性。方法:选取2022年10月至2023年10月西安交通大学医学院第一附属医院肿瘤放疗科收治的82例局部晚期宫颈癌患者,根据随机数表法将其分为观察组和对照组,每组41例。观察组予以CT引导下的192Ir三维后装放疗,对照组行常规二维后装放疗。对比两组近期疗效、血清肿瘤标志物指标、治疗安全性及生存质量。结果:观察组的治疗总有效率为97.56%,高于对照组的80.49%,差异有统计学意义(χ^(2)=6.116,P<0.05),治疗后血清肿瘤标志物糖类抗原125(CA125)、鳞状细胞癌抗原(SCC)水平低于对照组,差异有统计学意义(t=11.352、5.507,P<0.05);观察组的放射性直肠炎发生率为7.32%,放射性膀胱炎发生率为4.88%,低于对照组的24.39%和21.95%,差异有统计学意义(χ^(2)=4.479、5.143,P<0.05);观察组治疗后的宫颈癌治疗功能评价量表(FACT-Cx)评分(生理状况、社会/家庭状况、情感状况、功能状况及附加关注)高于对照组,差异有统计学意义(t=6.150、7426、9.341、10.029、8.623,P<0.05)。结论:CT引导下的192Ir三维后装放疗对局部晚期宫颈癌患者可达到良好近期疗效,且安全性更高,有助于促进患者生存质量进一步改善。
Objective:To investigate the short-term efficacy and safety of three dimensional(3D)brachytherapy with 192Ir under computed tomography(CT)-guidance in patients with locally advanced cervical carcinoma.Methods:A total of 82 patients with locally advanced cervical carcinoma,who admitted to the Department of Tumor Radiotherapy of the First Affiliated Hospital of Xi'an Jiaotong University from October 2022 to October 2023,were selected,and they were divided into observation group and control group according to random number table method,with 41 cases in each group.The observation group received 3D brachytherapy with 192Ir under computed tomography(CT)-guidance,and control group received routine two-dimensional(2D)brachytherapy.The short-term efficacy,serum tumor markers,treatment safety and quality of life of the two groups were compared.Results:In observation group,the total effective rate was 97.56%,which was significantly higher than 80.49%in control group(χ^(2)=6.116,P<0.05).The levels of glucose chain antigen 125(CA125)and squamous cell carcinoma(SCC)antigen of serum tumor markers after treatment of observation group were significantly lower than those of control group(t=11.352,5.507,P<0.05),respectively.The incidences of radiation proctitis and radiation cystitis of observation group were respectively 7.32%and 4.88%,which were significantly lower than 24.39%and 21.95%of control group(χ^(2)=4.479,5.143,P<0.05),respectively.After treatment,the scores of functional assessment of cancer therapy-cervix(FACT-Cx)scale(physiological status,social/family status,emotional status,functional status and additional concerns)of observation group were significantly higher than those of control group,and the differences of them between two groups were significantly(t=6.150,7426,9.341,10.029,8.623,P<0.05),respectively.Conclusion:3D brachytherapy with 192Ir under CT-guidance can achieve favorable short-term efficacy and higher safety on patients with locally advanced cervical carcinoma,which is helpful to further improve the qu
作者
高静
蔡梦娇
陆珏
孙玄子
张惠
许林萍
王珍
Gao Jing;Cai Mengjiao;Lu Jue;Sun Xuanzi;Zhang Hui;Xu Linping;Wang Zhen(Department of Tumor Radiotherapy,The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine,Xi'an 710000,China)
出处
《中国医学装备》
2024年第12期56-60,共5页
China Medical Equipment
基金
陕西省自然科学基础研究计划项目(2023-JC-QN-1909)。
关键词
CT引导
铱-192(192Ir)三维后装放疗
局部晚期宫颈癌
近期疗效
安全性
Computed tomography(CT)guidance
Three-dimensional(3D)brachytherapy with Iridium-192
Locally advanced cervical carcinoma
Short-term efficacy
Safety
