摘要
近视的发病机制涉及复杂的视网膜-脉络膜-巩膜调节过程,其中Wnt/β-catenin通路作为重要的信号通路在近视的发展中起关键作用。Wnt/β-catenin通路的激活与近视的严重程度呈正相关,抑制该通路可能有助于延缓近视进展。近视患者血液中Wnt/β-catenin通路抑制剂DKK-1(Dickkopf-1)表达水平明显偏低,而DKK-1的补充则有可能减缓眼球轴向生长和近视漂移,这为基于Wnt/β-catenin通路的治疗策略开辟了新的研究方向。
The etiology of myopia involves a complex regulatory process of the retina-choroid-sclera axis,wherein the Wnt/β-catenin pathway plays a pivotal role as a significant signaling pathway in myopia development.Studies indicate that activation of the Wnt/β-catenin pathway correlates positively with the severity of myopia,and inhibiting this pathway may potentially slow the progression of myopia.Moreover,individuals with myopia exhibit significantly reduced levels of DKK-1(Dickkopf-1)in their blood,and supplementation of DKK-1 may mitigate axial elongation of the eye and progression of myopia.These findings pave the way for novel research directions in therapeutic strategies based on the Wnt/β-catenin pathway.
作者
阿地来·艾克拜尔
丁琳
Adilai·Aikebaier;Ding Lin(Xinjiang Medical University,Urumqi 830054,China)
出处
《国际眼科纵览》
2024年第6期433-437,共5页
International Review of Ophthalmology
基金
新疆维吾尔自治区自然科学基金面上项目(2022D01C134)。
