摘要
小胶质细胞胞葬作用是指小胶质细胞吞噬受损和死亡细胞的过程,具有抗炎和促损伤修复的作用。最新研究表明,小胶质细胞胞葬在阿尔茨海默病(Alzheimer's disease,AD)病理过程中发挥重要作用,可能是治疗AD的新靶标。因此本文综述了小胶质细胞胞葬与AD病理机制的关系以及胞葬相关分子作为AD治疗靶标的潜力,以期为AD的治疗提供新思路和新方法。
Microglia efferocytosis,the process by which microglia phagocytose damaged and dead cells,has antiinflammatory and pro-damage repair effects.Recent studies have shown that microglia efferocytosis plays a crucial role in the pathogenesis of Alzheimer’s disease(AD)and may be a novel therapeutic target for AD.This paper reviews the relationship between microglia efferocytosis and AD pathogenesis and the potential of using efferocytosis-related molecules as therapeutic targets for AD.The aim of this review is to provide new ideas and approaches for the treatment of AD.
作者
马驰远
王新志
刘向哲
韩珍珍
郭明
刘昊飞
李潇
MA Chiyuan;WANG Xinzhi;LIU Xiangzhe;HAN Zhenzhen;GUO Ming;LIU Haofei;LI Xiao(Department of Brain Disease Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;the First Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450000;Zhengzhou Jinshui District General Hospital,Zhengzhou 450000;Zhengzhou Weilai Road Street Elder Care Center,Zhengzhou 450000;Henan University of Chinese Medicine,Zhengzhou 450046)
出处
《中国比较医学杂志》
CAS
北大核心
2024年第11期163-168,共6页
Chinese Journal of Comparative Medicine
基金
中医药传承与创新“百千万”人才工程(岐黄工程)-国家中医药领军人才支持计划(国中医药人教发[2018]12号)
河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号)
河南省科技攻关项目(242102311277)
国家资助博士后研究人员计划(GZC20240442)
河南省自然科学基金(232300420271)
河南省中医药科学研究专项(2022JDZX116)。
关键词
小胶质细胞
胞葬
阿尔茨海默病
认知障碍
神经炎症
microglia
efferocytosis
Alzheimer’s disease
cognitive impairment
neuroinflammation
