摘要
溃疡性结肠炎(UC)是一种消化系统难治性疾病,临床表现复杂,难以根治。肠络受损是UC发生的重要原因。祖国医学认为,“毒损肠络”是UC发生的关键病机,且以不同的形式影响UC的发展及预后,如湿热瘀毒久积损伤肠络使UC反复发作,缠绵难愈。现代医学认为UC的发生发展与免疫反应密切相关,炎症因子损伤肠黏膜这一病理机制与“毒损肠络”高度吻合。中医治疗方面提出UC治法,通过解毒通络恢复各免疫细胞之间的平衡,减轻肠道炎症,促进肠黏膜愈合,以期为临床防治UC提供指导。
Ulcerative colitis(UC)is a refractory disease of digestive system,which has complex clinical manifestations and is difficult to cure.The damage of intestinal collaterals is an important cause of UC.Traditional Chinese medicine(TCM)believes that"toxic damage to the intestinal collaterals"is a key pathogenesis of UC,and it affects the development and prognosis of UC in different forms.For example,prolonged accumulation of dampness,heat,blood stasis,and toxins can damage the intestinal collaterals,causing UC to recur and persist for a long time,making it difficult to cure.Modern medicine believes that the occurrence and development of UC is closely related to immune response,and the pathological mechanism of inflammatory factors damaging intestinal mucosa is highly consistent with"toxic damage to intestinal collaterals".In terms of TCM treatment,the UC treatment method is proposed to restore the balance between immune cells,reduce intestinal inflammation and promote intestinal mucosal healing by detoxifying and clearing collaterals,in order to provide guidance for the clinical prevention and treatment of UC.
作者
段丽敏
袁媛
赵强
韩捷
DUAN Limin;YUAN Yuan;ZHAO Qiang;HAN Jie(Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Gastroenterology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《医学综述》
CAS
2025年第1期92-97,共6页
Medical Recapitulate
基金
河南省中医药科学研究专项课题(2019JDZX2114)。
关键词
溃疡性结肠炎
毒邪学说
络病学说
毒损肠络
免疫炎症
Ulcerative colitis
Theory of toxic damage
Theory of collateral diseases
Toxic damage to the intestinal collaterals
Immunoinflammation
