摘要
目的:探讨DME患者行雷珠单抗治疗前后OCT参数、实验室血清指标的表达差异变化及预后影响因素。方法:回顾性分析2022.4-2023.11月收治的92例(130眼)DME患者,对比患者的各项指标。治疗4个月后根据黄斑区中央视网膜厚度将患者分为预后良好组70例(90眼)和预后不良组22例(40眼),分析DME患者行雷珠单抗治疗的预后影响因素。结果:治疗后4个月患者SND高度、CST均降低(P<0.05);治疗后1个月IL-8、VEGF、IL-6水平均降低,PEDF升高(P<0.05);预后组患者年龄、病变分级、病情分类、SND高度、CST、VEGF、IL-6表达水平对比差异显著(P<0.05);病变分级、CST、VEGF、IL-6为DME患者行雷珠单抗治疗的预后独立危险因素(P<0.05)。结论:玻璃体腔注射雷珠单抗治疗DME可改善其OCT参数,降低血清IL-8、VEGF、IL-6水平,提高PEDF水平。黄斑水肿分期、CST、VEGF及IL-6水平可对早期患者预后水平预测提供重要参考。
Objective:To investigate the differential expression of optical coherence tomography(OCT)parameters,laboratory serum indicators and prognostic factors in patients with diabetic macular edema(DME)before and after treatment with Ranibizumab.Methods:Retrospective analysis of 92 DME patients(130 eyes)admitted from April 2022 to November 2023,comparing various indicators of the patients.After 4 months of treatment,patients were divided into a good prognosis group of 70 cases(90 eyes)and a poor prognosis group of 22 cases(40 eyes)based on the thickness of the central retina in the macular area.The prognostic factors of DME patients treated with ranibizumab were analyzed.Results:After 4 months of treatment,the SND height and CST of the patient decreased(P<0.05);After one month of treatment,the average levels of IL-8,VEGF,and IL-6 decreased,while PEDF increased(P<0.05);There were significant differences(P<0.05)in age,lesion grading,disease classification,SND height,CST,VEGF,and IL-6 expression levels among patients in the prognostic group;Disease grading,CST,VEGF,and IL-6 are independent prognostic risk factors for DME patients treated with ranibizumab(P<0.05).Conclusion:Ranibizumab treatment of DME can improve its OCT parameters,reduce serum levels of IL-8,VEGF,IL-6,and increase the level of PEDF.However,observation of macular edema stage,CST,VEGF,and IL-6 levels before treatment can provide an important reference for predicting the prognosis of early patients.
作者
苏梦茹
范晓雁
谢海蓉
郑鑫雨
孙杏红
SU Meng-ru;FAN Xiao-yan;XIE Hai-rong;ZHENG Xin-yu;SUN Xing-hong(Department of Ophthalmology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu,210008,China)
出处
《现代生物医学进展》
CAS
2024年第21期4082-4085,共4页
Progress in Modern Biomedicine
基金
江苏省中医药科技发展计划面上项目(MS2022078)。
关键词
黄斑水肿
光学相干断层扫描
血管内皮生长因子
Macular edema
Optical coherence tomography
Vascular endothelial growth factor
