摘要
目的探讨对于急性淋巴细胞白血病(ALL)患儿采用培门冬酶(PEG-Asp)进行治疗的临床疗效及对凝血功能的影响。方法选取2020年6月至2023年6月于泰安市妇幼保健院接受治疗的ALL患儿119例作为研究对象,按照随机数字表法分为对照组(n=59)和观察组(n=60)。对照组予以左旋门冬酰胺酶(L-Asp)治疗,观察组使用PEG-Asp治疗,比较两组临床疗效、凝血指标、不良反应以及住院指标。结果观察组与对照组治疗有效率比较差异无统计学意义(P>0.05);治疗前两组纤维蛋白原(FIB)、凝血活酶时间(APTT)、凝血酶原时间(PT)比较差异无统计学意义(P>0.05);治疗后观察组FIB水平低于对照组,APTT高于对照组,差异有统计学意义(P<0.05),观察组PT水平与对照组比较差异无统计学意义(P>0.05);观察组胃肠道反应、尿淀粉酶升高以及呕吐发生率与对照组比较差异无统计学意义(P>0.05),观察组肝功能受损、过敏发生率低于对照组,差异有统计学意义(P<0.05);观察组住院天数短于对照组,用药次数少于对照组,差异有统计学意义(P<0.05)。结论对于ALL患儿使用PEG-Asp治疗效果较好,但其易造成凝血功能异常,使用时应及时监测患儿凝血情况,该药物半衰期较长故用药频率低且住院时间较短,安全性高,过敏反应少。
Objective To explore the clinical effect of PEG-Asp in the treatment of acute lymphoblastic leukemia(ALL)and its effect on coagulation function.Methods A total of 119 children with ALL who received treatment in Tai'an Maternal and Child Health Hospital from June 2020 to June 2023 were selected as the study objects,and were divided into control group(n=59)and observation group(n=60)according to random number table method.The control group was treated with L-asparaginase(L-Asp),and the observation group was treated with PEG-Asp.The clinical efficacy,coagulation indexes,adverse reactions and hospitalization indexes were compared between the two groups.Results There was no significant difference between the observation group and the control group(P>0.05).There was no significant difference in fibrinogen(FIB),thromboplastin time(APTT)and prothrombin time(PT)between the two groups before treatment(P>0.05).After treatment,the FIB level of the observation group was lower than that of the control group,and the APTT level was higher than that of the control group,the difference was statistically significant(P<0.05),and the PT level of the observation group was not statistically significant(P>0.05).There was no significant difference in the incidence of gastrointestinal reaction,urinary amylase increase and vomiting between the observation group and the control group(P>0.05).The incidence of liver function impairment and allergy in the observation group was lower than that in the control group,with statistical significance(P<0.05).The days of hospitalization in the observation group were shorter than those in the control group,and the Times of medication were less than those in the control group,the difference was statistically significant(P<0.05).Conclusion For ALL children using PEG-Asp treatment effect is better,but it is easy to cause children's coagulation function abnormalities,the use of children should be timely monitoring of coagulation,the drug has a longer half-life,so the frequency of use is low and shorter hosp
作者
焦顺
JIAO Shun(Department of Pediatrics,Tai'an maternal and child health care hospital,Tai'an 271000,China)
出处
《中国药物经济学》
2024年第11期80-83,87,共5页
China Journal of Pharmaceutical Economics
