摘要
目的探讨超声清创联合重组人表皮生长因子(RhEGF)对肛周脓肿合并感染患者创面愈合及肛门功能的影响。方法选取2022年8月至2023年8月南宁市第三人民医院收治的73例肛周脓肿合并感染患者作为研究对象,按随机数字表法分为观察组(n=36)和对照组(n=37)。对照组给予RhEGF治疗,观察组采用超声清创联合RhEGF治疗。比较两组腐肉脱落时间、上皮出现时间、创面愈合时间、创面细菌清除率、视觉模拟评分法(VAS)评分、经皮氧分压、创面血流量、括约肌最大收缩压、直肠静息压及肛管静息压。结果观察组腐肉脱落时间、上皮出现时间及创面愈合时间短于对照组(P<0.05);治疗1、3、7 d观察组创面细菌清除率高于对照组,治疗3、7 d观察组VAS评分低于对照组,差异有统计学意义(P<0.05);治疗前,两组经皮氧分压、创面血流量比较差异无统计学意义(P>0.05);治疗后,观察组经皮氧分压及创面血流量高于对照组(P<0.05);治疗前,两组括约肌最大收缩压、直肠静息压及肛管静息压比较差异无统计学意义(P>0.05);治疗后观察组括约肌最大收缩压及直肠静息压较对照组明显改善(P<0.05),两组肛管静息压比较差异无统计学意义(P>0.05)。结论超声清创联合RhEGF治疗肛周脓肿合并感染效果显著,可有效清除细菌,促进创面愈合,改善肛门功能。
Objective To explore the effect of ultrasonic debridement combined with recombinant human epidermal growth factor(RhEGF)on wound healing and anal function in patients with perianal abscess complicated with infection.Methods A total of 73 patients with perianal abscess combined with infection admitted to the Third People's Hospital of Nanning from August 2022 to August 2023 were selected as the study objects,and were divided into observation group(n=36)and control group(n=37)according to random number table method.The control group was treated with RhEGF,and the observation group was treated with ultrasonic debridement combined with RhEGF.The rotting time,epithelial time,wound healing time,wound bacterial clearance rate,VAS score,percutaneous partial pressure of oxygen,wound blood flow,maximum sphincter systolic pressure,rectal resting pressure and anal canal resting pressure were compared between the two groups.Results The time of rotting flesh shedding,epithelial appearance and wound healing in observation group were shorter than those in control group(P<0.05).After 1,3 and 7 days of treatment,the wound bacterial clearance rate of observation group was higher than that of control group,and the VAS score of observation group was lower than that of control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in percutaneous partial pressure of oxygen and wound blood flow between the two groups(P>0.05).After treatment,percutaneous partial pressure of oxygen and wound blood flow in observation group were higher than those in control group(P<0.05).Before treatment,there was no significant difference in the maximum sphincter systolic pressure,rectal resting pressure and anal canal resting pressure between the two groups(P>0.05).After treatment,the maximum sphincter systolic pressure and rectal resting pressure in the observation group were significantly improved compared with the control group(P<0.05),and there was no statistical significance in the resting pressure of anal
作者
陆大卿
陆玉晶
覃晓虹
LU Da-Qing;LU Yu-Jing;QIN Xiao-Hong(Department of General Surgery,The Third People's Hospital of Nanning,Nanning 530003,China;Department of Clinical Laboratory,923 Hospital,Joint Logistic Support Force,PLA,Nanning 530021,China)
出处
《中国药物经济学》
2024年第11期71-74,共4页
China Journal of Pharmaceutical Economics
关键词
超声清创
肛周脓肿
重组人表皮生长因子
微循环
肛门功能
Ultrasonic debridement
Perianal abscess
Recombinant human epidermal growth factor
Microcirculation
Anal function
