摘要
目的研究穴位埋针联合氢溴酸山莨菪碱及吲哚美辛栓在尿石症急性肾绞痛中的应用价值。方法选择2021年5月至2023年4月该院急诊科收治的泌尿系结石引发的急性肾绞痛患者176例作为研究对象。按照随机数字表法分为观察组、对照组,每组88例,观察组采取穴位埋针联合氢溴酸山莨菪碱及吲哚美辛栓治疗,对照组则接受氢溴酸山莨菪碱及吲哚美辛栓治疗,比较两组的总有效率、证候积分、视觉模拟评分法(VAS)评分、生活质量综合评定问卷(GQOLI-74)评分、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、5-羟色胺、P物质、盐酸哌替啶使用率、镇痛起效时间和维持时间。结果观察组总有效率为90.91%,明显高于对照组的79.55%,差异有统计学意义(P<0.05)。两组不同时间点的VAS评分存在时间、组间、交互效应(F_(时间)=130.020,P_(时间)<0.001;F组间=9.030,P_(组间)<0.001;F_(交互)=1291.230,P_(交互)<0.001)。单因素方差分析结果显示,各组中VAS评分均随治疗时间呈逐渐降低趋势,差异均有统计学意义(P<0.05)。多变量方差分析结果显示,治疗后30 min、60 min、120 min、24 h观察组的VAS评分明显低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组各项证候积分、GQOLI-74评分及IL-6、CRP、TNF-α、5-羟色胺、P物质水平比较,差异均无统计学意义(P>0.05)。治疗2周后,观察组各项证候积分均低于对照组,各项GQOLI-74评分均高于对照组,IL-6、CRP、TNF-α、5-羟色胺、P物质水平均明显低于对照组,差异均有统计学意义(P<0.05)。观察组盐酸哌替啶使用率低于对照组,镇痛起效时间均短于对照组,且镇痛维持时间明显长于对照组,差异均有统计学意义(P<0.05)。结论穴位埋针联合氢溴酸山莨菪碱及吲哚美辛栓治疗尿石症急性肾绞痛的效果较理想,可快速降低疼痛,且镇痛作用持久,可促进症状减轻,同时减轻炎性反应,�
Objective To investigate the value of acupuncture embedding combined with hydrobromic acid ansisodamine and indomethacin suppository in the treatment of acute renal colic caused by urolithiasis.Methods A total of 176 patients with acute renal colic caused by urolithiasis admitted to the department of emergency in this hospital from May 2021 to April 2023 were selected as the study subjects.According to the random number table method,the patients were divided into observation group and control group,with 88 cases in each group.The patients in the observation group were treated with acupuncture embedding,hydrobromic acid ansisodamine and indomethacin suppositories,while the patients in the control group were treated with hydrobromic acid ansisodamine and indomethacin suppositories.The total effective rate,syndrome score,visual analog scale(VAS),comprehensive quality of life assessment questionnaire(GQOLI-74),interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),serotonin,substance P and the use rate of pethidine hyrochloride were compared between the two groups.Results The total effective rate of the observation group was 90.91%,which was significantly higher than the control group′s 79.55%,and the difference was statistically significant(P<0.05).There were time,inter group and interaction effects in the VAS scores at different time points in the two groups,and the differences were statistically significant(F_(time)=130.020,P_(time)<0.001);F_(group)=9.030,P_(group)<0.001;F_(interaction)=1291.230,P_(interaction)<0.001).The results of one-way ANOVA showed that VAS scores in all groups gradually decreased as the treatment time,and the differences were statistically significant(P<0.05).The results of multivariate analysis of variance showed that the VAS scores of the observation group were significantly lower than those of the control group at 30 min,60 min,120 min,and 24 h after treatment,the differences were statistically significant(P<0.05).There was no statistically significant difference i
作者
刘丰
魏尧
邓超
宋明霞
方秀鹏
唐华
戚与仪
郑闽川
LIU Feng;WEI Yao;DENG Chao;SONG Mingxia;FANG Xiupeng;TANG Hua;QI Yuyi;ZHENG Minchuan(Department of Emergency,Jinshan District Hospital of Integrated Traditional and Western Medicine,Shanghai 201501,China;Department of Acupuncture and Moxibustion,Jinshan District Hospital of Integrated Traditional and Western Medicine,Shanghai 201501,China)
出处
《检验医学与临床》
CAS
2024年第24期3708-3713,共6页
Laboratory Medicine and Clinic
基金
上海市金山区医药卫生科技创新资金项目(2023-WS-23)。
关键词
尿石症
急性肾绞痛
穴位埋针
氢溴酸山莨菪碱
吲哚美辛栓
urolithiasis
acute renal colic
acupuncture embedding
hydrobromic acid ansisodamine
indomeacin suppository
