摘要
目的 探究中医药治疗低氧型肺动脉高压(Hypoxic pulmonary hypertension,HPH)的核心药物,并通过低氧联合Su5416(Hypoxia+Su5416,HySu)诱导的PH小鼠模型进行药效验证。方法 收集中国知网、万方、维普中与中医药治疗HPH相关的文献,通过纳排标准筛选并建立数据库,输入中医传承辅助系统(V2.5)软件进行用药规律挖掘。建立HySu-PH小鼠模型,通过力竭运动跑台、血氧饱和度、右心室压、右心肥厚指数检测,对核心药物进行药效评价。结果 筛选出治疗HPH的相关方剂102首,涉及中药共158种,药物频率前5位分别为丹参、川芎、黄芪、葶苈子、当归,用药类别中活血化瘀药、补虚药使用最高,丹参是核心用药。构建HySu-PH小鼠模型,给予2周的丹参制剂丹参注射液治疗,丹参注射液明显提升HySu-PH小鼠的体质量(P<0.01)、血氧饱和度(P<0.05)、力竭位移(P<0.01)和力竭时间(P<0.05),降低右心室收缩压(P <0.01)和右心肥厚指数(P<0.01)。结论 丹参是治疗HPH的核心药物,丹参制剂丹参注射液可有效的治疗HySu-PH。
Objective To investigate the core drugs of traditional Chinese medicine(TCM)for the treatment of hypoxic pulmonary hypertension(HPH),and to verify the drug efficacy by hypoxia combined with Su5416(Hypoxia+Su5416,HySu)-induced PH mouse model.Methods Relevant literatures on TCM treatment of HPH in China Knowledge Network,Wanfang,Weipu were collected,screened and set up a database through the nerf criteria,and inputted into the software of traditional Chinese medicine inheritance assistance platform(V2.5)for the excavation of medication law.The HySu-PH mouse model was established,and the core drugs were evaluated for drug efficacy through force exhaustion exercise running table,blood oxygen saturation,right ventricular pressure,and right heart hypertrophy index test.Results The 102 relevant formulas for the treatment of HPH were screened,involving a total of 158 traditional Chinese medicines,and the top 5 drug frequencies were Salvia miltiorrhiza,Rhizoma Chuanxiong,Astragalus membranaceus,Draba hebecarpa,and Angelica sinensis,with the highest use of blood-activating and blood-stasis removing drugs,and deficiency-tonifying drugs in the categories of drugs used,and Salvia miltiorrhiza was the core drug used.HySu-PH mouse models were constructed and given 2 weeks of treatment with the danshen preparation Danshen injection.Danshen injection significantly elevated body weight(P<0.01),oxygen saturation(P<0.05),displacement of exhaustion(P<0.01),and duration of exhaustion(P<0.05),and lowered the right ventricular systolic blood pressure(P<0.01)and the right cardiac hypertrophy index(P<0.01).Conclusion Salvia miltiorrhiza is a core drug for the treatment of HPH,and the danshen preparation Danshen injection can effectively treat HySu-PH.
作者
董政委
张敏
丁云
邢作英
于瑞
赵孟依
樊官伟
王永霞
朱明军
DONG Zhengwei;ZHANG Min;DING Yun;XING Zuoying;YU Rui;ZHAO Mengyi;FAN Guanwei;WANG Yongxia;ZHU Mingjun(The First Affiliated Hospital of Henan University of Chinese Medicine,Heart Center/National Regional(Traditional Chinese Medicine)Cardiovascular Diagnosis and Treatment Center,Zhengzhou 450000,China;Shanxi University of Traditional Chinese Medicine,Taiyuan 030000,China;The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Transformation,Tianjin 300193,China;Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Acupuncture and Moxibustion of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第8期2016-2022,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省国家中医药传承创新中心科研专项(2023ZXZX1130):丹参酮IIA靶向结合DYRK1A介导PKA/TFAM通路抗肺动脉高压血管重塑的机制研究,负责人:董政委。
关键词
低氧型肺动脉高压
核心用药
数据挖掘
中医传承辅助平台
药效评价
丹参
Hypoxic pulmonary hypertension
Core medication
Data mining
Traditional Chinese medicine inheritance assistance platform
Medicinal efficacy evaluation
Salvia miltiorrhiza
