介入联合依达拉奉右莰醇、丁苯酞治疗急性脑梗死并颈动脉中重度狭窄的疗效及安全性

The Efficacy and Safety of Combined Intervention with Edaravone Dexcamphenol and Butylphthalide in Treating Acute Cerebral Infarction with Severe Stenosis of the Cervical Artery Validation

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摘要探究介入联合依达拉奉右莰醇、丁苯酞治疗急性脑梗死并颈动脉中重度狭窄的疗效及安全性。选取2021年3月—2023年3月湖北民族大学附属民大医院收治的急性脑梗死并颈动脉中重度狭窄患者108例,采用随机数字表法分为两组,各54例。所有患者均行静脉溶栓和颈动脉支架植入术治疗,对照组采用丁苯酞治疗,研究组采用丁苯酞联合依达拉奉右莰醇治疗。治疗90 d后,比较两组的美国国立卫生研究院卒中量表(NIHSS)评分、简易精神状态量表(MMSE)评分、脑血管外周阻力、平均血流速度、血清脑特异性蛋白(S100B)、血清基质细胞衍生因子-1(SDF-1)、全血高切黏度、全血低切黏度、改良Rankin量表(mRS)评分、巴塞尔指数(Barthel index,BI),记录不良反应。治疗后,两组患者的NIHSS评分、血管外周阻力、血清S100B、全血高切黏度、全血低切黏度、mRS评分均降低,MMSE评分、平均血流速度、血清SDF-1、BI评分均升高(P<0.05)。研究组治疗后NIHSS评分、血管外周阻力、血清S100B、全血高切黏度、全血低切黏度、mRS评分低于对照组,MMSE评分、平均血流速度、血清SDF-1、BI评分高于对照组(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。介入联合依达拉奉右莰醇、丁苯酞治疗急性脑梗死并颈动脉中重度狭窄,有助于改善患者的血液流变学,调节神经因子表达,促进神经功能恢复,且安全性良好。 To investigate the efficacy and safety of intervention combined with edaravone dexamethasone and butylphthalide in the treatment of acute cerebral infarction with moderate-to-severe carotid artery stenosis,108 patients with acute cerebral infarction and moderate-to-severe stenosis of carotid artery admitted to Minda Hospital Affiliated to Hubei Minzu University from March 2021 to March 2023 were selected.They were divided into 2 groups,each with 54 cases,using the random number table method.All patients were treated with intravenous thrombolysis and carotid artery stenting,the control group was treated with butalbital,and the study group was treated with butalbital combined with edaravone dexamethasone.After 90 d of treatment,the National Institutes of Health stroke scale(NIHSS)score,the brief mental state exercise(MMSE)score,cerebrovascular peripheral resistance,mean blood flow velocity,serum brain-specific protein(S100B),serum stromal cell-derived factor-1(SDF-1),whole-blood high cut-off viscosity,whole-blood low cut-off viscosity,modified rankin scale(mRS)score,barthel index(BI),and adverse reactions were recorded.After treat-ment,NIHSS score,peripheral vascular resistance,serum S100B,whole blood high cut viscosity,whole blood low cut viscosity,and mRS scores were decreased;MMSE scores,mean blood flow velocity,serum SDF-1,and BI scores were increased in both groups(P<0.05).NIHSS score,peripheral vascular resistance,serum S100B,whole blood high cut viscosity,whole blood low cut viscosity,and mRS scores were lower,MMSE score,mean blood flow velocity,serum SDF-1,and BI scores were higher(P<0.05)in the study group than in the control group after treatment.There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Intervention combined with edaravone dexamethasone and butylphthalide in the treatment of acute cerebral infarction with moderate-to-severe carotid artery stenosis can help to improve the patient's haemorheology,regulate the expression of neurofac-tors,and promote the rec

作者满劲进张泽莲陈娟李贵友李晶 MAN Jinjin;ZHANG Zelian;CHEN Juan;LI Guiyou;LI Jing(Minda Hospital of Hubei Minzu University,Enshi 445000,China;Enshi Central Hospital,Enshi 445000,China)

机构地区湖北民族大学附属民大医院恩施州中心医院

出处《药物生物技术》 CAS 2024年第5期538-542,共5页 Pharmaceutical Biotechnology

关键词急性脑梗死颈动脉中重度狭窄介入治疗依达拉奉右莰醇丁苯酞 Acute cerebral infarction Moderate-to-severe carotid artery stenosis Intervention Edaravone dexamethasone Butylphthalide

分类号 R743.3 [医药卫生—神经病学与精神病学]