摘要
Diabetic osteoporosis(DOP)is a serious complication of diabetes mellitus.It is urgent to explore efficient clinical treatment strategies for DOP.It has been found that mesenchymal stem cell-derived extracellular vesicles(MSC-EVs),as an emerging cell-free therapy,show great potential in DOP treatment.MSC-EVs can effectively promote bone formation,inhibit bone resorption,and modulate the inflammatory microenvironment by delivering cargoes of microRNAs,long non-coding RNAs,and proteins to target cells,thereby ameliorating bone loss in DOP.However,there are limited reports on the treatment of DOP with MSC-EVs.To evoke more attention to this potential strategy,this article summarised the extant literature on MSC-EVs for DOP to provide new directions for further research and to promote the application of MSC-EVs in the clinical management of DOP.
