摘要
理想的脑卒中后吞咽障碍动物模型可以有助于深度了解其生理和病理的发病过程,从而推动该疾病研究的发展。不同类型的模型存在多样性,研究者可以根据其研究内容和实际需求来选择合适的动物模型。目前常用的脑卒中后吞咽障碍动物模型造模方法包括光化学法、线栓法、结扎双侧颈总动脉法、Ⅶ型胶原酶诱导右侧脑出血+损伤右侧舌下神经法。本文从实验动物的选择、理论依据、造模方法和模型特点等方面对上述动物模型进行综述、比较其优缺点。与其他3种方法相比,光化学法具有高存活率、定点精准损伤的特点,且在从细胞和分子水平上评估脑可塑性方面具有一定优势。
An ideal animal model of post-stroke dysphagia(PSD)can aid in deeply understanding its physiological and pathological processes,thus promoting the development of research on this disease.Different types of models exhibit diversity,allowing researchers to choose the appropriate animal model based on their research content and practical needs.Currently,common methods for creating animal models of PSD include photochemical induction,thread embolism,bilateral common carotid artery ligation,and typeⅦcollagenase-induced right hemorrhage plus right hypoglossal nerve injury.This article provides an overview and comparison of the advantages and disadvantages of the above animal models in terms of experimental animal selection,theoretical basis,modeling methods,and model characteristics.Compared with the other three methods,the photochemical method has the characteristics of high survival rate and precise damage at specific sites,and it holds certain advantages in evaluating brain plasticity at the cellular and molecular levels.
作者
田聪
饶泽华
饶彤
陆梦
袁思
慕容志苗
岳增辉
TIAN Cong;RAO Zhehua;RAO Tong;LU Meng;Yuan Si;MURONG Zhimiao;YUE Zenghui(College of Acupuncture and Tuina,Hunan University of Traditional Chinese Medicine,Changsha 410208,China)
出处
《神经损伤与功能重建》
2024年第12期766-769,共4页
Neural Injury and Functional Reconstruction
基金
国家自然科学基金青年科学基金项目(针刺对假性延髓麻痹后皮质吞咽中枢脑区功能重组及神经结构重塑研究,No.82205298,基于星形胶质细胞介导神经血管耦合探究电针改善脑卒中后吞咽障碍的机制,No.82405591)
湖南省自然科学基金面上项目(电针抑制CK LF1-CCR4轴调控小胶质细胞极化以缓解PSS的机制,No.2023JJ30462)
湖南省中医药管理局中医药科研一般项目(基于吞咽神经环路调控的针刺治疗脑卒中后吞咽障碍有效性及安全性临床疗效研究,No.B2024007)
湖南中医药大学校级科研项目(基于吞咽感觉信号传导通路“SLN-DSG”探讨电针调节PSD模型小鼠口咽期吞咽运动的作用机制,No.Z2023XJYQ07,电针干预脑卒中肢体痉挛小胶质细胞“铁-炎”稳态机制研究,No.Z2023YYJJ02)。
