摘要
代谢相关脂肪性肝病(MAFLD,旧称非酒精性脂肪肝)是一种典型的肥胖引起的肝病,被认为是最常见的肝脏疾病。MAFLD是一种复杂的疾病,与多种遗传、表观遗传和环境有关,其发病机制尚不完全清楚。近年来研究表明氧化应激水平的升高是导致MAFLD形成的重要原因之一。核因子E2相关因子2(Nrf2)信号通路是重要的抗氧化应激通路,Nrf2通路能减少活性氧(ROS)的产生,增加抗氧化酶及蛋白的表达,而中药可以通过激活Nrf2介导的抗氧化反应来降低肝细胞的氧化应激,从而起到预防及治疗代谢相关脂肪性肝病的作用。对通过调节Nrf2途径减少ROS过量产生,产生抗氧化反应及降低炎症反应,发挥MAFLD治疗作用的单味中药及复方进行总结归纳,为发现预防和治疗MAFLD的高效中药提供参考。
Metabolism-associated fatty liver disease(MAFLD,formerly known as nonalcoholic fatty liver disease)is a typical obesity-induced liver disease and is considered to be the most common liver disease.MAFLD is a complex disease associated with a variety of genetic,epigenetic,and environmental associations,and the mechanisms of its pathogenesis are still not fully understood.Recent studies have shown that elevated levels of oxidative stress are one of the major causes of MAFLD formation.The nuclear factor E2-related factor 2(Nrf2)signaling pathway is an important anti-oxidative stress pathway,and the Nrf2 pathway reduces the production of reactive oxygen species(ROS)and increases the expression of antioxidant enzymes and proteins,whereas traditional Chinese medicines can reduce the oxidative stress of hepatocytes by activating the Nrf2-mediated antioxidant response,thus playing a role in the prevention and treatment of metabolism-related fatty liver disease.We summarize the single herbs and compound formulas that can reduce the overproduction of ROS,generate antioxidant responses and reduce inflammatory responses through regulating the Nrf2 pathway,and play a therapeutic role in the treatment of MAFLD,so as to provide a reference for the discovery of highly effective herbs for the prevention and treatment of MAFLD.
作者
杨金彪
陈星彤
周云越
杨帅虎
杨蕊红
王乔
薛爽
牛雯颖
YANG Jinbiao;CHEN Xingtong;ZHOU Yunyue;YANG Shuaihu;YANG Ruihong;WANG Qiao;XUEShuang;NIU Wenying(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
出处
《药物评价研究》
CAS
北大核心
2024年第11期2681-2687,共7页
Drug Evaluation Research
基金
国家自然科学基金资助项目(82274405)。
关键词
代谢相关脂肪性肝病
非酒精性脂肪肝
氧化应激
核因子E2相关因子2(Nrf2)
活性氧
中药
metabolism-associated fatty liver disease
non-alcoholic fatty liver disease
oxidative stress
nuclear factor E2-related factor 2(Nrf2)
reactive oxygen species
traditional Chinese medicine
