摘要
勃起功能障碍是男科常见、难治的疾病,且发病率高,目前,认为神经、内皮、平滑肌的协同作用是阴茎勃起的关键,而阴茎海绵体中大量的成纤维细胞在勃起行为中的作用往往被忽略。成纤维细胞处于阴茎海绵体内细胞分子网络的中心,可以调控海绵体微环境的动态平衡,介导阴茎勃起,从而为勃起功能障碍治疗提供新靶点。本团队认为,瘀血是导致勃起功能障碍的核心病机,是造成海绵体微环境失调的关键病理因素,且瘀血与勃起功能障碍患者海绵体微观病理改变相契合。因此,本团队积极探讨成纤维细胞介导阴茎勃起与中医学理论的相关性,将其与中医学理论相结合并运用于临床,提出活血化瘀法可以调节海绵体微环境,改善成纤维细胞介导的勃起功能障碍,为勃起功能障碍的中医药治疗提供新思路。
Erectile dysfunction has a high incidence rate and is a difficult-to-treat condition in male urology.The synergistic effect of nerves,endothelium,and smooth muscles plays a crucial role in penile erection.However,the role of the many fibroblasts in the corpus cavernosum of the penis during erection is often overlooked.Fibroblasts are at the center of the cellular and molecular network in the corpus cavernosum of the penis,regulating the dynamic balance of the cavernosal microenvironment and mediating penile erection,thus providing a novel target for treating erectile dysfunction.Blood stasis primarily causes erectile dysfunction,thereby serving as a crucial pathological factor leading to the imbalance of the cavernosal microenvironment.Blood stasis also corresponds to the microscopic pathological changes in the corpus cavernosum of patients with erectile dysfunction.Therefore,this study explored the correlation between fibroblast-mediated penile erection and traditional Chinese medicine theories,integrating it with clinical practice.This study proposes that activating blood and resolving stasis can regulate the cavernosal microenvironment and improve fibroblast-mediated erectile dysfunction.This study also provides novel insights for treating erectile dysfunction with traditional Chinese medicine.
作者
张思政
曹
罗成龙
程皓洋
张琪
焦拥政
ZHANG Sizheng;CAO Yan;LUO Chenglong;CHENG Haoyang;ZHANG Qi;JIAO Yongzheng(Department of Andrology of Guang′anmen Hospital,Chinese Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Integrated Traditional Chinese and Western Medicine,First People′s Hospital of Dongcheng District,Beijing 100077,China)
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2024年第11期1495-1500,共6页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金项目(No.82074446)
中国中医科学院科技创新工程项目(No.C12021A02202)。
关键词
勃起功能障碍
成纤维细胞
海绵体微环境
活血化瘀
erectile dysfunction
fibroblasts
cavernosal microenvironment
activating blood and resolving stasis
