摘要
铁作为一种必需的微量元素,是体内许多化学过程的辅助因子。当体内游离铁过量蓄积时,会通过Fenton反应产生大量活性氧簇(reactive oxygen species,ROS),引起氧化应激;氧化应激是细胞衰老的常见驱动因素,而细胞衰老的特征表现为不可逆的细胞周期停滞,与各种生理过程和增龄相关疾病密切相关。本文综述了铁相关的氧化应激与衰老之间的联系及其在心血管疾病发生发展中的作用,并针对二者探讨心血管疾病的潜在治疗策略。
Iron,as one of the essential microelements,is a cofactor of many chemical processes in the human body.However,when free iron is accumulated excessively in the body,a large number of reactive oxygen species(ROS)and oxygen metabolic by-products will be produced through the Fenton reaction,which will cause oxidative stress when the regulation is out of balance.It is worth noting that oxidative stress is a driver of cell senescence which is characterized by irreversible cell cycle arrest and is related to various physiological processes and a wide range of age-related diseases.This review summarizes the relationship between iron-related oxidative stress and aging and their pathological roles in cardiovascular diseases.
作者
殷铭泽
王孙云澍
李泽
李凯峰
邢文娟
张海锋
YIN Ming-ze;WANG SUN Yun-shu;LI Ze;LI Kai-feng;XING Wen-juan;ZHANG Hai-feng(Fifth Cadet Regiment,School of Basic Medical Science,Air Force Medical University,Xi’an 710032,Shaanxi,China;Medical Research and Experiment Center,Medical College,Yan’an University,Yan’an 716099,Shaanxi,China;Experimental Teaching Center,School of Basic Medical Sciences,Air Force Medical University,Xi’an 710032,Shaanxi,China;Key Laboratory of Aerospace Medicine,Ministry of Education,School of Aerospace Medicine,Air Force Medical University,Xi’an 710032,Shaanxi,China)
出处
《心脏杂志》
CAS
2024年第6期690-696,共7页
Chinese Heart Journal
基金
国家自然科学基金项目(32371239,32071107)
陕西省重点研发计划(2021SF-067,2021KJXX-21)。
关键词
铁
活性氧簇
氧化应激
细胞衰老
心血管疾病
iron
reactive oxygen species
oxidative stress
cellular senescence
cardiovascular diseases
