摘要
水凝胶具有高含水量、高保水性、黏附性、生物相容性好等特点,被广泛应用于生物医学领域。水凝胶涂层则能够在保留水凝胶本身优点基础上,赋予固体基材表面如抗菌、抗污等多功能性。最近,水凝胶涂层已经能够在不同基材表面实现厚度可控且牢固结合,这为水凝胶涂层在植入式医疗器械表面的修饰增加了更多可能性。首先概述了生物医用水凝胶涂层的研究背景,包括水凝胶的特点、水凝胶涂层的发展以及研究现状。之后归纳了现阶段常用水凝胶涂层在植入式医疗器械表面的制备方法及原理,包括表面桥接法、表面引发法,并阐述了近年来出现的新型水凝胶涂层制备方法。在此基础上,总结了水凝胶涂层的应用场景,包括其在润滑防污性、药物递送、生物传感方面的应用。随后,对近年来水凝胶涂层的研究热点进行了总结,包括智能响应性水凝胶涂层、组织工程领域及水凝胶性能等。最后对未来水凝胶涂层的发展提出了展望。
Hydrogel is a hydrophilic polymer cohesive system with a three-dimensional reticulated structure,which has the characteristics of high water content,high water retention,adhesion and good biocompatibility,and is widely used in biomedical materials.Hydrogel coatings retain the advantages of hydrogel and pave the way for improved lubricity,biocompatibility and flexibility of solid surfaces.By changing the formulation of hydrogel,it is also possible to give the surface of solid substrate such as antibacterial and antifouling properties and other multifunctionality,which has a widespread development in the biomedical field.With the development of the medical treatment,implantable and interventional medical devices are increasingly used to treat a variety of diseases,such as stents and medical guidewire catheters.However,the materials commonly used for various medical devices have poor lubrication and antifouling properties,which experience high friction with surrounding tissues and are likely to suffer biofouling,resulting in a series of side effects such as inflammatory reactions and thrombosis.Therefore,these implantable medical devices usually require complex surface modifications during application to improve performance and biocompatibility.Among a variety of surface modification techniques,hydrogel coatings have received extensive attention with their structural stability,biocompatibility and controlled thickness.Recently,hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates,which have more possibilities for the modification of hydrogel coatings on the surface of implantable medical devices.In this review,the research background of biomedical hydrogel coatings was firstly outlined,including the characteristics of hydrogels,the development history of hydrogel coatings and the current research status.The common hydrogel coating preparation methods and principles at this stage were presented.Surface bridging method refers that the two ends of a bridge molecule can
作者
王雅楠
张凡军
罗日方
王云兵
WANG Ya'nan;ZHANG Fanjun;LUO Rifang;WANG Yunbing(College of Biomedical Engineering,Sichuan University,Chengdu 610065,China;National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu 610065,China)
出处
《表面技术》
EI
CAS
CSCD
北大核心
2024年第23期1-15,共15页
Surface Technology
基金
国家自然科学基金项目(32371401)
四川大学青年科技学术带头人培育项目(2023-08)。
关键词
水凝胶涂层
生物医学
植入式医疗器械
制备方法
应用场景
hydrogel coating
biomedical
implantable and interventional medical devices
preparation methods
application scenarios
