摘要
目的 探讨立体定向微创手术治疗脑胶质瘤患者的临床疗效及对神经功能的影响。方法 根据手术方法的不同将80例脑胶质瘤患者分为微创组(n=10,立体定向微创手术)和对照组(n=70,传统开颅手术)。比较两组患者的临床疗效、神经功能[格拉斯哥昏迷量表(GCS)、美国国立卫生研究院卒中量表(NIHSS)]、神经肽指标[催产素(OT)、精氨酸加压素(AVP)、β-内啡肽(β-EP)]及并发症发生情况。结果 微创组患者的总缓解率高于对照组,差异有统计学意义(P﹤0.05)。术后3个月,两组患者GCS评分均高于本组术前,NIHSS评分均低于本组术前,微创组患者GCS评分高于对照组,NIHSS评分低于对照组,差异均有统计学意义(P﹤0.05)。术后3个月,两组患者OT、AVP、β-EP水平均低于本组术前,微创组患者OT、AVP、β-EP水平均高于对照组,差异均有统计学意义(P﹤0.05)。两组患者的并发症总发生率比较,差异无统计学意义(P﹥0.05)。结论 与传统开颅手术相比,立体定向微创手术治疗脑胶质瘤的临床疗效显著,且可保护患者的神经功能。
Objective To explore the clinical efficacy of stereotactic minimally invasive surgery in cerebral glioma patients and its influence on neurological function.Method According to different surgical methods,80 patients with cerebral glioma were divided into minimally invasive group(n=10,stereotactic minimally invasive surgery)and control group(n=70,traditional craniotomy).The clinical efficacy,neurological function[Glasgow coma scale(GCS),National Institutes of Health stroke scale(NIHSS)],neuropeptide indexes[oxytocin(OT),arginine vasopressin(AVP),β-endorphin(β-EP)]and complications were compared between the two groups.Result The total response rate in minimally invasive group was higher than that in control group,and the difference was statistically significant(P<0.05).Three months after surgery,the GCS scores in both groups were higher than those before surgery,and the NIHSS scores were lower than those before surgery,the GCS score in minimally invasive group was higher than that in control group,and the NI-HSS score was lower than that in control group,and the differences were statistically significant(P<0.05).Three months after surgery,the levels of OT,AVP andβ-EP in both groups were lower than those before surgery,and the levels of OT,AVP andβ-EP in minimally invasive group were higher than those in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Compared with traditional craniotomy,stereotactic minimally invasive surgery has a significant clinical effect in the treatment of cerebral glioma,and can protect the neurological function of patients.
作者
赵墨
张跃欣
苗统
魏康康
王一明
周国平
ZHAO Mo;ZHANG Yuexin;MIAO Tong;WEI Kangkang;WANG Yiming;ZHOU Guoping(Department of Neurosurgery,Nanyang Central Hospital,Nanyang 473000,He'nan,China)
出处
《癌症进展》
2024年第21期2337-2340,共4页
Oncology Progress
关键词
脑胶质瘤
立体定向微创手术
传统开颅手术
神经功能
cerebral glioma
stereotactic minimally invasive surgery
traditional craniotomy
neurological function
