摘要
目的观察院内制剂潜阳育阴颗粒改善阴虚阳亢型1级高血压患者的血压、中医证候评分和血管功能的临床疗效。方法选取2020年6月—2021年11月就诊于我院心内科、高血压病研究所门诊及体检中心的受试者90例,符合方案纳入标准共84例。将入组的84例阴虚阳亢型1级高血压患者,随机分为试验组和对照组,借助R统计软件给定代码,产生所接受处理的组别,其中脱落12例(试验组和对照组各6例),完成试验72例,最终试验组37例和对照组35例。对照组为生活方式干预,试验组为生活方式加用潜阳育阴颗粒。对两组患者的治疗前及第4,8,12周降压情况,以及两组患者治疗前后中医症状、颈动脉的极速脉博波传导速度(PWV)、颈动脉内中膜厚度(IMT)、肝肾功能、血脂等的影响。结果与对照组相比,试验组的收缩压差值变化幅度较对照组差异有统计学差异(P<0.05),舒张压差值差异无统计学意义(P>0.05)。随访期间血压比较,两组第8周、12周收缩压组间比较差异有统计学意义(P<0.05)。与对照组相比,试验组的中医证候总积分较低,差异有统计学意义(P<0.05);试验组治疗后在眩晕、头痛等症状改善较对照组差异有统计学意义(P<0.05)。治疗前后颈动脉收缩起始脉搏波传导速度(PWV-BS)、收缩结束时脉搏波传导速度(PWV-ES)和IMT比较,试验组较对照组组间、组内比较差异均无统计学意义(P>0.05)。两组治疗前后血生化、心电图等均无明显变化。结论潜阳育阴颗粒对阴虚阳亢型1级高血压患者的血压降压治疗和改善中医证候方面具有优势,在血管功能改善方面观察期内无明显优势。
Objective To observe the clinical effect of the hospital preparation Qianyang Yuyin in improving the blood pressure,Traditional Chinese medical science premonitory score,and blood vessel function of grade 1 hypertension of yin deficiency and yang hyperactivity type.Methods There were 84 patients had grade 1 hypertension of yinxu yangkang were stochastic divided into two groups.The code was given with the help of R statistical software to generate the treated groups,covering 12 cases of shedding(There were 6 cases in experimental group and 6 cases in control group),72 cases of completing the test(37 and 35 cases in the experimental group and the control group respectively),and the control group was lifestyle intervention,the experimental group was lifestyle plus Qianyang Yuyin granule as the experimental group.The effects of hypotension,TCM syndrome,carotid PWV,carotid IMT,liver and kidney function and blood lipid of the two groups were observed for 3 months.Independent sample t-test or Wilcoxon rank sum test andχ2 test were used to compare the efficacy and safety indexes of the experimental group and the control group,and paired sample t-test or Wilcoxon signed rank test were used to compare the efficacy and safety indexes before and after treatment.Results In the aspect of TCM syndrome improvement,compared with the control group,the total score of TCM syndrome in experimental group was lower,and the difference was statistically significant(P<0.05).In terms of TCM syndromes,the improvement of vertigo,headache and other syndromes after experimental group was statistically significant compared with the control group(P<0.05).Compared with the control group,the change range of systolic blood pressure difference of Qianyang Yuyin granule was significantly higher than that of the control group(P<0.05),and the diastolic blood pressure was not statistically significant(P>0.05).During the follow-up period,there was a significant difference between the two groups in systolic blood pressure at the 8th and 12th weeks(P<0.05
作者
地娜拉·加力肯
韩雪玲
孔雪
张金波
邹冲
DINALA Jialiken;HAN Xueling;KONG Xue;ZHANG Jinbo;ZOU Chong(The Affiliated Hospital of Nanjing University Hospital of Traditional Chinese Medicine,Nanjing 210029,China)
出处
《西部医学》
2024年第12期1792-1797,共6页
Medical Journal of West China
基金
江苏省六大高峰人才项目(WSN-091)
江苏省中医药管理局课题(JD2019SZ01)
江苏省卫生健康委项目(LK2021003)。
