摘要
动脉粥样硬化(atherosclerosis,AS)是慢性心力衰竭和冠心病等心血管疾病的病理基础,涉及巨噬细胞炎症和泡沫细胞形成等病理机制,发病率逐年升高且趋于年轻化。中医药治疗本病的疗效确切、安全性高、特色突出。胡志希教授基于中医整体观念与“心-脾-肾一体观”,认为心、脾、肾与AS发病密切相关,指出AS的病机以脾肾亏虚为基础,以痰瘀互结为关键,以本虚标实为核心,治疗原则为扶正祛邪、标本兼治,治法为健脾益肾、祛瘀化痰,即补益脏腑之经气亏虚,祛除脉道之病理产物。以中医理论为指导,结合现代医学研究,简要梳理中药复方、中成药、单味中药和中药药理成分治疗AS的作用机制和通路靶点等,以期为中医药治疗AS提供理论依据和新思路。
Atherosclerosis(AS)is the pathological basis of cardiovascular diseases including chronic heart failure and coronary heart disease,which involves pathological mechanisms such as macrophage inflammation and foam cell formation.The incidence rate is increasing year by year,with a notable trend towards affecting younger individuals.The efficacy of Chinese medicine in treating AS is well-established,with high safety and distinctive features.Based on the holistic concept of Chinese medicine and the"heart-spleen-kidney integrated view",Professor HU Zhixi believes that the conditions of heart,spleen,and kidney are closely related to the onset of AS.It is pointed out that,as to the pathogenesis of AS,the deficiency of spleen and kidney is the basis,the intermingled phlegm and stasis is the key,and deficiency in the root while excess in the manifestation is the core.In accordance,the treatment principles are reinforcing healthy qi to eliminate pathogenic factors,and treating both the root and manifestation.The treatment methods involve supplementing the spleen and kidney,and eliminating stasis and resolving phlegm,that is,supplementing deficient qi in the zang-fu organs and removing the pathological products in the blood vessels.Guided by the theory of Chinese medicine and combined with modern medical research,the article briefly reviews the mechanism of action and pathway targets of the compound formulas,Chinese patent medicines,Chinese medicines and their pharmacological components in the treatment of AS in order to provide theoretical basis and new ideas for the treatment of AS in Chinese medicine.
作者
廉坤
廖晓倩
雷竣显
李鑫
李琳
胡志希
LIAN Kun;LIAO Xiaoqian;LEI Junxian;LI Xin;LI Lin;HU Zhixi(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)
出处
《湖南中医药大学学报》
CAS
2024年第11期2102-2110,共9页
Journal of Hunan University of Chinese Medicine
基金
国家自然科学基金项目(82274412)
广东省重点领域研发项目(2020B1111100001)
湖南省自然科学基金项目(2020JJ4062,2020JJ5408)。
关键词
心-脾-肾一体观
动脉粥样硬化
脾肾亏虚
痰瘀互结
抗炎
heart-spleen-kidney integrated view
atherosclerosis
spleen and kidney deficiency
intermingled phlegm and stasis
anti-inflammation
